浙江医学2017，Vol.39Issue(23)：2079-2083,后插1,6.DOI:10.12056/j.issn.1006-2785.2017.39.23.2017-1288
血浆和肽素及精氨酸加压素受体基因多态性对脑出血后脑梗死的预测价值
Predictive value of plasma copeptin level and arginine vasopressin receptor gene polymorphism for acute cerebral infarction after spontaneous intracerebral hemorrhage
金孟浩 1郑伟明2
作者信息
- 1. 325000 温州医科大学附属第一医院神经外科
- 2. 温州市中西医结合医院神经外科
- 折叠
摘要
Abstract
Objective To evaluate predictive value of plasma copeptin and arginine vasopressin receptor (AVPR) gene polymorphism for acute cerebral infarction after spontaneous intracerebral hemorrhage (ICH).Methods One hundred and forty seven patients with acute ICH in basal ganglia were enrolled in the study.The plasma copeptin levels were measured and AVPR gene polymorphism was detected.Patients underwent magnetic resonance diffusion-weighted imaging(DWl) examinations within 4 weeks of onset.The plasma copeptin levels and AVPR gene polymorphism were compared between patients with and without acute cerebral infarction,and the risk factors of acute cerebral infarction after spontaneous intracerebral hemorrhage were analyzed with logistic regression.Results They were 55 cases had infarction after ICH (infarction group) and 92 cases had no infarction (non-infarction group).There were no significant differences clinical data between two groups (P＞0.05).The plasma copeptin level in infarction group was significantly higher than that in non-infarction group (P＜0.05).The frequencies of A allele and AA genotype in rs28632197 of AVPR1B gene in infarction group were higher than those of non-infarction group (both P＜ 0.05).The ROC curve analysis showed the AUC of plasma copeptin was 0.746 in prediction of cerebral infarction after ICH,the sensitivity was 63.0％,82.8％ with a Youden's index of 0.458.Conclusion Acute cerebral infarction after spontaneous intracerebral hemorrhage is associated with plasma copeptin levels and AVPR gene polymorphism,indicating both indicators may have predictive value for acute cerebral infarction after spontaneous intracerebral hemorrhage.关键词
和肽素/精氨加压素受体/脑出血/脑梗死Key words
Copeptin/Arginine vasopressin receptor/Intracerebral hemorrhage/Cerebral infarction引用本文复制引用
金孟浩,郑伟明..血浆和肽素及精氨酸加压素受体基因多态性对脑出血后脑梗死的预测价值[J].浙江医学,2017,39(23):2079-2083,后插1,6.
