浙江医学2017，Vol.39Issue(23)：2089-2092,2097,5.DOI:10.12056/j.issn.1006-2785.2017.39.23.2017-533
HIF-1α基因多态性与CO中毒患者急性期中枢神经损伤的相关性研究
Association of HIF-1α gene polymorphism with central nervous injury in patients with acute carbon monoxide poisoning
摘要
Abstract
Objective To investigate the association between HIF-1 α gene polymorphism and central nervous injury in patients with acute carbon monoxide poisoning.Methods One hundred and ninety one patients with carbon monoxide poisoning in acute stage were enrolled in the study,including 86 cases with central nervous injury according to MRI examination.The single nucleotide polymorphisms of HIF-1 α gene rs3783752,rs4899056,rs1957757 and rs10873142 loci were detected with DNA direct sequencing.Results The frequencies of TT genotype in rs4899056 and GG genotype of rs10873142 in MRI abnormal group were significantly lower than those in MRI normal group (both P＜0.05).The linkage disequilibrium analysis found that haploid type(rs3783752-rs4899056-rs1957757) in normal group had high linkage (D'＞0.9,r2＞0.8),while not in abnormal group.There were significant differences in haploid type (rs3783752-rs4899056-rs1957757-rs10873142) between patients with abnormal MRI and normal MRI (P＜0.05),the significant difference was found in CTTG haploid type (P＜0.05),while the difference trend was found in TCCA haploid type (P=0.057).Conclusion HIF-1 α gene polymorphism is related to central nerve damage in patients with carbon monoxide poisoning.关键词
一氧化碳中毒/低氧诱导因子-1α/基因多态性/中枢神经损伤Key words
Carbon monoxide poisoning/Hypoxia inducible factor-1α/Gene polymorphism/Central nerve injury引用本文复制引用
李晟,刘伟,池学锋,谢雪蓓,陈潜妙,屠巍,吴赛华,张媛媛..HIF-1α基因多态性与CO中毒患者急性期中枢神经损伤的相关性研究[J].浙江医学,2017,39(23):2089-2092,2097,5.基金项目
温州市公益性科技计划项目(Y20150168) （Y20150168）
