浙江医学2017，Vol.39Issue(23)：2098-2100,2105,4.DOI:10.12056/j.issn.1006-2785.2017.39.23.2017-1916
子痫前期患者25-OH-VD、VDR蛋白水平变化及维生素D干预效果的研究
Relationship of serum 25-hydroxy-vitamin D level and vitamin D receptor expression in placenta with preeclampsia and intervention effect of vitamin D
摘要
Abstract
Objective To investigate serum levels of 25-hydroxy-vitamin D (25-OH-VD) and expression of vitamin D receptor (VDR) protein in placenta chorion tissue of patients with preeclampsia,and the intervention effect of vitamin D.Methods Two hundred puerperants with cesarean section were enrolled in the study,including 80 cases of normal pregnancy (group C) and 120 cases with preeclampsia (the study group).The study group was further divided into two groups with 60 cases in each,group A had no vitamin D intervention and group B received vitamin D drops 600IU/d affer the diagnosis of preeclampsia.Serum 25-OH-VD levels and the expression of VDR protein in placental chorion tissue were determined and compared among 3 groups.Results Serum 25-OH-VD levels at the termination of pregnancy were higher than those at the 20 week of gestation in all three groups (P＜0.05).At 20 weeks after pregnancy,the serum 25-OH-VD level of group C was higher than that of groups A and B (all P＜0.05),there was no significant difference between groups A and B (P ＞0.05).At the termination of pregnancy,the serum 25-OH-VD levels of groups B and C were higher than those of group A (P＜0.05),there was no significant difference between group B and C (P ＞0.05).The expression level of VDR protein in the chorion tissue of groups B and C was higher than that of group A at the termination of pregnancy (P＜0.05),there was no significant difference between group B and C (P ＞ 0.05).The incidence of severe preeclampsia in group B was significantly lower than that in group A (P＜0.05).Conclusion Vitamin D supplementation may improve serum 25-OH-VD levels in preeclampsia women,up-regulate VDR protein expression in chorion tissue,and reduce the occurrence of eclampsia.关键词
25-羟基维生素D/维生素D受体/子痫前期Key words
25-hydroxy vitamin D/Vitamin D receptor/Preeclampsia引用本文复制引用
邱海凡,王荣跃,邱笑飞,王繁..子痫前期患者25-OH-VD、VDR蛋白水平变化及维生素D干预效果的研究[J].浙江医学,2017,39(23):2098-2100,2105,4.基金项目
温州市科技局计划项目(Y20160345) （Y20160345）
