浙江医学2017，Vol.39Issue(23)：2110-2113,4.DOI:10.12056/j.issn.1006-2785.2017.39.23.2017-375
慢性阻塞性肺疾病急性加重患者肺康复护理的临床应用研究
Application of pulmonary rehabilitation for patients with acute exacerbations of chronic obstructive pulmonary disease
摘要
Abstract
Objective To assess the application of pulmonary rehabilitation for patients with acute exacerbations of chronic obstructive pulmonary disease (AECOPD).Methods One hundred and thirty five patients with AECOPD were randomly assigned to two groups:patients in PR group (n=71) received simultaneous pulmonary rehabilitation and 12-week follow-up rehabilitation in addition to conventional treatment,and patients in control group (n=64) received conventional treatment only.The length of hospital stay,cost of hospitalization and therapeutic course of antibiotic were compared between the two groups.The COPD Assessment test (CAT) score,modified British Research Council (mMRC) score,6-minute walk distance (6MWD) and FEV1％ were evaluated,and serum TNF-α and IL-6 levels were measured and compared in two groups before and after treatment.The frequency of acute exacerbation and readmission in the follow-up period were compared between two groups.Results The length of hospital stay,cost of hospitalization and therapeutic course of antibiotics in PR group were less than those in control group (P＜0.05).There were no significant differences in CAT score,mMRC,6MWD,FEV1％,and serum TNF-α and IL-6 levels between two groups before treatment (P ＞0.05).After treatment the CAT score and mMRC in PR group were significantly higher than control group [(25.70 ± 4.69) vs.(22.13 ± 4.27) and(2.41 ± 0.73)vs (2.10 ± 0.66),P＜ 0.05],serum TNF-α and I L-6 levels were significantly lower than those in control group [(5.94 ± 2.04)pg/ml vs.(5.12 ± 1.89)pg/ml and (4.29 ± 1.04) pg/ml vs (3.85 ± 1.07)pg/ml,P＜0.05],the 6MWD in PR group was higher than that in control group [(341.55 ±84.40)m vs (301.72 ± 72.76)m,P＜0.05],while there was no significant difference in FEV1％ [(55.72 ± 9.28)％ vs (53.10 ± 8.27)％,P ＞0.05] between two groups.The frequency of acute exacerbation and readmission was less in PR group than those in control group in the follow-up period (P＜0.05).Conclusion The application of pulmonary rehabilitation in patients with AECOPD can shorten the length of hospital stay and decrease medical costs,improve quality of life,physical performance,and the lung function;it also can alleviate inflammation of acute exacerbation and minimize the risk of readmission.关键词
肺康复/慢性阻塞性肺疾病/急性加重/综合评估Key words
Pulmonary rehabilitation/Chronic obstructive pulmonary disease/Acute exacerbations/Comprehensive evaluation引用本文复制引用
陶学霞,徐月花,邵银燕..慢性阻塞性肺疾病急性加重患者肺康复护理的临床应用研究[J].浙江医学,2017,39(23):2110-2113,4.基金项目
浙江省中医药科研基金计划项目(2016ZA160) （2016ZA160）
