浙江医学2017，Vol.39Issue(23)：2114-2117,4.DOI:10.12056/j.issn.1006-2785.2017.39.23.2017-1914
老年人血压昼夜节律与认知功能障碍的关系研究
Association between blood pressure circadian rhythm and cognitive impairments in the elderly
摘要
Abstract
Objective To explore the relationship between blood pressure circadian rhythm and cognitive impairments in the elderly.Methods Total 363 elderly subjects were enrolled in the study from Wuyunshan Sanatorium.The blood pressure was monitored and the cognition status was evaluated with Montreal Cognitive Assessment (MoCa).The relationship between the blood pressure rhythm and the cognitive impairments was analyzed.Results The blood pressure in both hypertension group and non-hypertension group mainly presented non-dipper type.The rate of the abnormal blood pressure rhythm was 77.5％ and 76.3％ in two groups,respectively.There was no significant difference in △MBP between two groups (P ＞0.05).The total MoCA scores of patients with non-dipper,super-dipper and reverse-dipper types were lower than that of those with dipper type (all P＜0.05),the total MocA scores of super-dipper and reverse-dipper groups were lower than that of non-dipper group,while the total MoCA score of reverse-dipper group was lower than super-dipper group (all P＜0.05).The scores of naming and delayed recall of super-dipper group and reverse-dipper group were lower than those of dipper group and non-dipper group (all P＜ 0.05).The score of attention of per-dipper group was lower than that of dipper group and non-dipper group (all P＜O.05).There were significant differences in the incidence of cognitive impairments among patients with different blood pressure rhythms (P＜ 0.05).Logistic regression analysis showed that the abnormal blood pressure rhythm was a risk factor for cognitive impairments in the elderly (OR=2.437,95％CI:1.480-4.012),particularly for reverse-dipper blood pressure (OR=5.305,95％CI:1.814-15.514).Conclusion The abnormal blood pressure circadian rhythm may be not associated with hypertension in the elderly,while abnormal blood pressure rhythm is a risk factor for cognitive impairments in the elderly.关键词
血压昼夜节律/认知功能障碍/老年人Key words
Blood pressure rhythm/Cognitive impairments/Elderly引用本文复制引用
吴都,王赛英..老年人血压昼夜节律与认知功能障碍的关系研究[J].浙江医学,2017,39(23):2114-2117,4.基金项目
杭州市农业与社会发展科研计划项目(20170533B77) （20170533B77）
