浙江医学2017，Vol.39Issue(23)：2121-2124,2128,5.DOI:10.12056/j.issn.1006-2785.2017.39.23.2017-577
预混胰岛素联合不同口服降糖药对2型糖尿病患者胰岛细胞功能及胰岛素敏感性的影响
Effect of premixed insulin combined with oral antidiabetic drugs on islet cell function and insulin sensitivity in patients with type 2 diabetes
摘要
Abstract
Objective To investigate the effects of premixed insulin combined with oral hypoglycemic agents on islet cell function and insulin sensitivity in patients with type 2 diabetes.Methods Eighty seven patients with type 2 diabetes were randomly assigned to four groups:21 patients treated with insulin aspart 30 alone (aspart 30 group),23 with insulin aspart 30+metformin (metformin group),22 with insulin aspart 30+acarbose (acarbose group) and 21 with insulin aspart 30+sitagliptin (sitagliptin group) for 12 weeks.The islet β-cell function,insulin sensitivity,glucose effectiveness and insulin dose were compared among 4 groups.Results Islet beta cell function was significantly improved in all groups after treatment.HOMA-S and Matsuda index were improved in 3 combined treatment groups after treatment.The improvement in HOMA-S of the metformin group [median 60.22 (1.95,180.85) ％] and acarbose group [median 46.60 (-0.15,105.85)％] were better than that of aspart 30 group[median 4.33(-25.7,43.00)％](P＜0.05).The glycosylated hemoglobin levels in metformin group[(6.58 ± 1.05)％] and acarbose group [(6.54± 0.96) ％] were significantly lower than that in aspart 30 group [(7.60 ± 1.10) ％](P＜0.05).The daily insulin dose of acarbose and metformin groups were lower other groups.Conclusion Premixed insulin combined with oral hypoglycemic agents can improve insulin sensitivity and hypoglycemic efficacy,and reduce the daily insulin dose in patients with type 2 diabetes,however,no further improvement of islet beta cell function is found.关键词
预混胰岛素/口服降糖药/胰岛β细胞功能/胰岛素敏感性Key words
Premixed insulin/Oral hypoglycemic agents/Islet beta cell function/Insulin sensitivity引用本文复制引用
徐芬娟,朱娟飞,沈中秋,张青森,宣少平,沈飞霞..预混胰岛素联合不同口服降糖药对2型糖尿病患者胰岛细胞功能及胰岛素敏感性的影响[J].浙江医学,2017,39(23):2121-2124,2128,5.基金项目
桐乡市科技计划项目(201403127) （201403127）
