浙江医学2017，Vol.39Issue(23)：2125-2128,4.DOI:10.12056/j.issn.1006-2785.2017.39.23.2016-1690
2015年杭州地区新生儿肠道病毒脑炎病原分型及临床特征
Pathogenic genotypes and clinical features of neonatal enterovirus-associated encephalitis in Hangzhou 2015
摘要
Abstract
Objective To analyze the pathogenic genotypes and clinical features of neonatal enterovirus-associated encephalitis in Hangzhou 2015.Methods Forty five newborns with intracranial infection admitted in Children's Hospital,Zhejiang University School of Medicine from May to September 2015 were enrolled in this study.The cerebrospinal fluid(CSF) samples from these newborns were collected and tested by RT-PCR.The pathogenic genotypes and clinical features of patients were analyzed.Results The enterovirus was positive in 17 CSF specimens (case group) with a positive rate of 37.8％.The glucose concentration in CSF of the case group was significantly higher (P＜0.05),however,the protein content in CSF of case group was significantly lower than those of control group (P＜0.05).There were no significant in clinical symptoms,including fever,jaundice,vomiting and cramps between case and control groups (P ＞0.05).Among 17 cases with positive intestinal virus in CSF,the Echo 30 virus was detected in 13 cases (76.5％),Echo 16 virus in 2 cases (11.8％) and CVB 2 virus in 2 cases (11.8％).Phylogenetic tree analysis showed that the homology between clinical isolates and reference strains was 89.6％-98.3％.Conclusion Echo 30 is the main pathogen of the outbreak of viral encephalitis among newborns in the summer of 2015 in Hangzhou.关键词
肠道病毒脑炎/新生儿/病原分型/临床特征Key words
Enterovirus encephalitis/Newborns/Pathogen parting/Clinical features引用本文复制引用
张琼,刘玉洁,李伟,尚世强..2015年杭州地区新生儿肠道病毒脑炎病原分型及临床特征[J].浙江医学,2017,39(23):2125-2128,4.基金项目
浙江省医药卫生一般计划项目(2015KYA119) （2015KYA119）
