浙江医学2017，Vol.39Issue(24)：2225-2227,2246,4.DOI:10.12056/j.issn.1006-2785.2017.39.24.2017-852
血液透析患者PCT水平与透析充分性、微炎症状态及营养不良的关系研究
Relationship of procalcitonin levels with dialysis adequacy, microinflammation and malnutrition in maintenance hemodialysis patients
摘要
Abstract
Objective To analyze the relationship of serum procalcitonin(PCT) level witi diaiysis adequacy,microinflammation and malnutrition in patients with maintenance hemodialysis (MHD).Methods One hundred and twenty MHD patients (study group) and 120 healthy subjects (control group) were included in the study.Blood urea nitrogen (BUN) level before and after dialysis was examined to calculate Kt/V.According to Kt/V value,MHD patients were divided into adequacy group (Kt/V ＞1.2,n=69) and non-adequacy group (Kt/V＜1.2,n=51).The levels of PCT,hs-CRP,hemoglobin and albumin were compared between study group and control group,and between adequacy group and non-adequacy group.The correlation of PCT with hs-CRP,hemoglobin,albumin and KtN in study group was analyzed.The value of PCT for identifying the dialysis adequacy in MHD patients was assessed by ROC curve analysis.Results Serum PCT and hs-CRP levels in study group were higher,while serum hemoglobin and albumin levels were lower than those in control group (all P＜0.05).Compared to the adequacy group,serum PCT and hs-CRP levels were higher,and hemoglobin level was lower in non-adequacy group (all P＜0.05),however there was no significant difference in serum hemoglobin level between two groups (P ＞0.05).In study group,serum PCT was positively correlated with hs-CRP (r=0.580,P＜0.05),negatively correlated with albumin,hemoglobin and Kt/V(r=-0.528,-0.462 and-0.554,all P＜0.05).ROC curve analysis showed that at a serum PCT cutoff value of 0.243 ng/ml,the sensitivity and specificity for identifying the dialysis adequacy in MHD patients were 0.85 and 0.50,respectively.Conclusion The increase of serum PCT level in MHD patients suggests inadequate dialysis,and aggravation of microinflammation and malnutrition.关键词
血液透析/降钙素原/透析充分性/微炎症状态/低蛋白血症Key words
Hemodialysis/Procalcitonin/Adequacy of hemodialysis/Microinflammation/Hypoproteinemia引用本文复制引用
杨丽莉,陈琦,王鸣,赵宁..血液透析患者PCT水平与透析充分性、微炎症状态及营养不良的关系研究[J].浙江医学,2017,39(24):2225-2227,2246,4.基金项目
浙江省科技计划项目(2014C33237) （2014C33237）
杭州市科技发展计划项目(20140733Q10) （20140733Q10）
