浙江医学2017，Vol.39Issue(24)：2232-2235,4.DOI:10.12056/j.issn.1006-2785.2017.39.24.2016-1582
急性心肌梗死相关基因的生物信息学分析
Bioinformatic analysis of genes associated with acute myocardial infarction
李丹辉 1朱建华 1乐健伟 1王志宇 1叶继辉 1范震1
作者信息
摘要
Abstract
Objective To perform bioinformatic analysis of genes associated with acute myocardial infarction.Methods The microarray data of myocardial infarction were downloaded from the Gene Expression Omnibus (GEO) database,and Qlucore Omics Explorer software was used to screen differentially expressed genes.The further analysis of differentially expressed genes were conducted by the on-line tools STRING and Panther.Results Among 200 differentially expressed genes,168 genes were related to interaction between proteins.These genes were involved in the biological process and molecular function of apoptosis signaling pathway and epithelial growth factor (EGF) receptor signaling pathway and so on.The analysis found that EPHB1,GRM6 and CD2BP2 genes were highly expressed in peripheral blood of patients with acute myocardial infarction.Conclusion Bioinformatic analysis shows that acute myocardial infarction may involve the interaction of multiple genes,which may provide useful information for studies on molecular mechanisms and potential therapeutic targets of acute myocardial infarction.关键词
心肌梗死/基因芯片/生物信息学Key words
Myocardial infarction/Bioinformatics/Gene microarray引用本文复制引用
李丹辉,朱建华,乐健伟,王志宇,叶继辉,范震..急性心肌梗死相关基因的生物信息学分析[J].浙江医学,2017,39(24):2232-2235,4.
