浙江医学2017，Vol.39Issue(24)：2241-2246,6.DOI:10.12056/j.issn.1006-2785.2017.39.24.2017-712
创伤性颅脑损伤与阿尔茨海默病发生关系的Meta分析
Relationship between traumatic brain injury and Alzheimer's disease: a Meta-analysis
摘要
Abstract
Objective To evaluate the relationship between traumatic brain injury (TBI) and Alzheimer's disease (AD).Methods The studies related the relationship TBI and AD were retrieved from database till September 2016,the quality of the literature was evaluated and analyzed with Stata 11.0.Results Twenty three non-randomized controlled trials (9 case-control studies,11 cohort studies and 3 cross-sectional studies) were included in the study.The total sample size was 2 184 210 cases (179 737 cases,2 004 473 controls).After 18 AD population-based studies were pooled,the results showed that TBI was a suspected risk factor for AD (OR=1.362,95％CI:0.996-1.863,P ＞0.05).After 5 TBI population based studies were pooled,the results showed that TBI was a risk factor for AD(OR=2.536,95％CI:1.763-3.648,P＜0.05).Conclusion TBI is associated with the occurrence of AD,and further large scale randomized controlled trials are needed for confirm the results.关键词
创伤性颅脑损伤/阿尔茨海默病/危险因素/Meta分析Key words
Traumatic brain injury/Alzheimer's disease/Risk factors/Meta-analysis引用本文复制引用
吴泽生,郭智东,陈友雷,陈方慧..创伤性颅脑损伤与阿尔茨海默病发生关系的Meta分析[J].浙江医学,2017,39(24):2241-2246,6.基金项目
浙江省中医药科技计划项目(2015ZA123) （2015ZA123）
