浙江医学2017，Vol.39Issue(24)：2257-2260,4.DOI:10.12056/j.issn.1006-2785.2017.39.24.2017-1178
CCLG-ALL2008诱导缓解方案化疗儿童急性淋巴细胞白血病的效果观察
Efficacy of CCLG-ALL2008 inducing remission chemotherapy in children with acute lymphoblastic leukemia
黄欣 1高清平1
作者信息
- 1. 430060湖北,武汉大学人民医院血液科
- 折叠
摘要
Abstract
Objective To evaluate the efficacy of CCLG-ALL2008 induction chemotherapy in children with acute lymphoblastic leukemia (ALL).Methods One hundred and thirty four children with ALL were treated with chemotherapy,including 67 cases receiving CCLG-ALL2008 induced remission chemotherapy (study group) and 67 cases receiving conventional multi-drug combination chemotherapy (control group).The curative effect,incidence of adverse reactions,expression of heat shock protein 90 (Hsp90) after chemotherapy and the 5-year survival rate were observed and compared between the two groups.Results The effective rate in study group was higher than that in control group (P＜0.05).There was no significant difference in incidence of adverse reactions between two groups (P ＞0.05).After chemotherapy,the expression of Hsp90 mRNA and protein in study group was lower,and the 5-year survival rate was higher than those in control group(P＜0.05).Conclusion CCLG-ALL2008 inducing remission chemotherapy is more effective than conventional chemotherapy in children with ALL.关键词
CCLG-ALL2008/儿童急性淋巴细胞白血病/Hsp90/预后Key words
CCLG-ALL2008/Childhood acute lymphoblastic leukemia/Hsp90 Prognosis引用本文复制引用
黄欣,高清平..CCLG-ALL2008诱导缓解方案化疗儿童急性淋巴细胞白血病的效果观察[J].浙江医学,2017,39(24):2257-2260,4.
