浙江医学2017，Vol.39Issue(24)：2267-2269,2284,4.DOI:10.12056/j.issn.1006-2785.2017.39.24.2017-530
125I粒子植入治疗高风险局限性前列腺癌临床研究
Efficacy of 125-iodine seeds branchytherapy for high-risk local prostate cancer
张丽霞 1陈金燕 1徐彩云 1王加奇1
作者信息
- 1. 310006杭州,浙江中医药大学附属第一医院(浙江省中医院)核医学科
- 折叠
摘要
Abstract
Objective To evaluate the clinical efficacy of transrectal ultrasound (TRUS)-guidecl transperineal permanent 125-iodine seeds branchytherapy for high-risk local prostate cancer.Methods Sixty six patients with biopsy-proven T3a prostate cancer admitted at the First Affiliated Hospital of Zhejiang Chinese Medical University between November 2013 and January 2016 were divided into two groups:36 cases received TRUS-guided transperineal permanent 125-iodine seeds branchytherapy under the guidance of three-dimensional treatment planning system (TPS) and 30 cases received laparoscopic radical prostatectomy.The survival,complications and T-PSA levels in two groups were compared.Results There were no significant differences in median disease free survival (DFS) and overall survival (OS) between two groups (P＞0.05).The postoperative uroclepsia and urethrostenosis were not observed in branchytherapy group,which were significantly better than those in prostatectomy group (P＜0.05).However,there were no significant differences in urethra irritation and urinary retention between two groups (P ＞0.05).T-PSA did not detected in 33.3％(12/36) and 83.3％(30/36)patients of branchytherapy group,and 73.33％(22/30) and 80.00％(24/30) patients of prostatectomy group at 3 and 6 months after operation,reaching biochemical recurrence-free survival.The WBC and PLT levels had no significant changes in branchytherapy group at 3 and 6 months after operation,compared with those before operation (P ＞0.05).Conclusion TRUS-guided transperineal permanent 125-iodine seeds branchytherapy is effective and safe for patients with high-risk local prostate cancer.关键词
前列腺肿瘤/近距离治疗/腹腔镜检查/前列腺癌根治术Key words
Prostatic neoplasms/Branchytherapy/Laparoscopy/Radical prostatectomy引用本文复制引用
张丽霞,陈金燕,徐彩云,王加奇..125I粒子植入治疗高风险局限性前列腺癌临床研究[J].浙江医学,2017,39(24):2267-2269,2284,4.
