中国中西医结合杂志2018，Vol.38Issue(1)：20-24,5.DOI:10.7661/j.cjim.20171115.286
分阶段综合治疗难治性幽门螺杆菌感染63例临床观察
A New Strategy (Step-by-step and Synthetic Therapy) for Refractory Helicobacter pylori Infection: An Observational Study of 63 Cases
马继征 1冯硕 2胡伏莲3
作者信息
- 1. 中国中医科学院广安门医院消化科 北京100053
- 2. 首都医科大学附属北京中医医院循证医学中心 北京100010
- 3. 北京大学第一医院消化科 北京100034
- 折叠
摘要
Abstract
Objective To observe the effect of'step-by-step and synthetic therapy'in treatment of participants with refractory H.pylori infection,who had failed in consensus based treatment.Methods A total of 63 participants,with more than 3 times of eradication failure within 2 years treated by consensus recommendations,were recruited in this cohort study.They received'step-by-step and synthetic therapy'[preliminary preparation (symptomatic treatment);standard antibiotic treatment (Rabeprazole plus Amoxicillin,Furazolidone and Bismuth Potassium Citrate for 10 days);consolidation therapy (Jinghua Weikang Capsule and Bismuth Potassium Citrate for 2 weeks) plus (Bacillus bifidus and Bismuth Potassium Citrate for 2 weeks)].13C breath test was rechecked after one month withdrawal.The eradition rate of H.pylori was observed.The relief of main symptoms were observed after withdrawal and one month after withdrawal.Results Totally 56 of 63 cases got negative conversion of H.pylori.Per protocol (PP) was 94.92％ (56/59) and intention to treat (ITT) was 88.89％ (56/63).Digestive symptoms,such as epigastric pain,bloating,heartburn,and constipation were obviously relieved after treatment (P ＜0.05,P ＜0.01).No serious adverse event occurred during the treatment course.Conclusion This new strategy (step-by-step and synthetic therapy) could significantly improve the eradication rate of refractory H.pylori infection.关键词
幽门螺杆菌/根除/耐药/难治性/新路径Key words
Helicobacter pylori/eradication/antibiotic resistance/refractory/new strategy引用本文复制引用
马继征,冯硕,胡伏莲..分阶段综合治疗难治性幽门螺杆菌感染63例临床观察[J].中国中西医结合杂志,2018,38(1):20-24,5.
