中国中西医结合杂志2018，Vol.38Issue(1)：25-28,4.DOI:10.7661/j.cjim.20171207.453
难治性胃食管反流病脾虚证CYP2C19基因表达及中药干预研究
CYP2C19 Gene Expression of Refractory Gastroesophageal Reflux Disease Patients with Pi Deficiency Syndrome and Intervention of Chinese Herbs
摘要
Abstract
Objective To observe the expression of CYP2C19 gene and the intervention of Chinese herbs (CHs) on refractory gastroesophageal reflux disease (RGERD) patients with Pi deficiency syndrome (PDS),and to observe the effect of proton pump inhibitor combined with Buzhong Yiqi Granule (BYG) on them with different metabolic types.Methods Totally 82 RGERD patients with PDS were genotyped by PCR-RFLP and assigned to strong metabolism group (68 cases) and weak metabolism group (14 cases).On the basis of PPI,all patients additionally took BYG for 4 successive weeks.Finally,the symptom score and total score of the RDQ scale (reflux disease questionnaire) and the symptoms of PDS were observed in the two groups.Results The scores of reflux,heartburn,noncardiogenic chest pain,and total score of the RDQ scale were significantly decreased after treatment in strong metabolism group (P ＜0.05）.Besides,tastelessness,poor appetite,tiredness,and loose stool occurred significantly in less patients of strong metabolism group (P ＜0.05).In weak metabolism group scores of acid regurgitation,reflux,heartburn,noncardiogenic chest pain,and total score of the RDQ were decreased after treatment (P ＞0.05).In addition,poor appetite,tiredness,and loose stool occurred significantly in less patients of week metabolism group (P ＜0.05).Conclusions The effect of drug intervention on RGERD patients with PDS was related to the expression of CYP2C19 gene.PPI combined with CHs for treatment of RGERD had more significantly effect on strong metabolic type of CYP2C19 gene.关键词
难治性胃食管反流病/脾虚证/CYP2C19/基因多态性Key words
refractory gastroesophageal reflux disease/Pi deficiency syndrome/CYP2C19/genetic polymorphism引用本文复制引用
肖茹萍,姜礼双,崔亚,陈健海,仲婕,卜平..难治性胃食管反流病脾虚证CYP2C19基因表达及中药干预研究[J].中国中西医结合杂志,2018,38(1):25-28,4.基金项目
国家自然科学基金资助项目(No.81673736) （No.81673736）
