中国中西医结合杂志2018，Vol.38Issue(1)：33-37,5.DOI:10.7661/j.cjim.20171207.298
滋阴泻火与益肾填精中药序贯治疗特发性真性性早熟女性患儿临床观察
Nourishing Yin Purging Fire and Tonifying Shen Replenishing Essence Chinese Herbal Medicine Sequential Therapeutic Scheme for Idiopathic True Precocious Puberty Female Children Patients
摘要
Abstract
Objective To observe the effect of nourishing yin purging fire (NYPF) and tonifying Shen replenishing essence (TSRE) Chinese herbal medicine sequential therapeutic scheme on pubertal development and bone development of idiopathic true precocious puberty female children patients.Methods Totally 54 (7-8 years old) female children with idiopathic true precocious puberty were randomly assigned to the Chinese medicine (CM) group (treated with NYPF and TSRE Chinese herbal medicine sequential therapeutic scheme) and the Western medicine (WM) group (treated with megestrol acetate),27 patients in each group.Besides,27 (7-8 years old) female children patients with idiopathic true precocious puberty were enrolled as an observational group,and they would not receive any treatment.Patients in the CM group took NYPF Recipe in the 1st stage (starting treatment to 10.5 years old) and TSRE Recipe in the 2nd stage (10.5-11.5 years old) respectively.Those in the WM group took megestrol acetate in the 1st stage and no drugs in the 2nd stage.Unit of mammillary nucleus,the volumes of uterus and ovary were detected in the 3 groups before treatment at the 1st stage and the 2nd stage of treatment.GnRH stimulating tests were performed.Luteinizing hormone (LH) bone mineral density of radius and serum osteocalcin were determined.The ratio of bone age difference/age difference was calculated.The final height of these girls could be predicted.Results After treated with the 1st phase,unit of mammillary nucleus,the volume of uterus,LH peak value decreased in the CM group,lower than those of the observational group at the same time period (P ＜0.05,P ＜0.01).The ratio of bone age difference/age difference,bone mineral density (BMD),serum osteocalcin decreased in the CM group,lower than those of the observational group and the WM group at the same time period (P ＜0.05,P ＜0.01).As for the WM group:After treated with the 1 st phase,unit of mammillary nucleus,the volume of uterus,LH peak value decreased in the WM group,lower than those of the observational group at the same time period (P ＜0.05,P ＜0.01);BMD increased (P ＜0.05).Unit of mammillary nucleus,the volume of uterus,the volume of ovary,BMD increased in the observational group (P ＜0.05).After treated with the 2nd phase in CM group,the volume of uterus was enlarged,higher than that of the observational group and the WM group at the same time period.Unit of mammillary nucleus,the volume of ovary,LH peak value increased in the CM group,higher than those of the WM group at the same time period.The ratio of bone age difference/age difference,BMD,serum osteocalcin increased in the CM group,but still lower than those of the observational group and the WM group at the same time period (P ＜0.05,P ＜0.01).The predicted final height increased after treated by NYPF and TSRE Chinese herbal medicine sequential therapeutic scheme,higher than that of WM group and the observational group as the same time period (P ＜0.01).Unit of mammillary nucleus,the volume of ovary,the volume of uterus,LH peak value were lower in the WM group than in the observational group at the same time period (P ＜0.05,P ＜0.01).But the ratio of bone age difference/age difference,BMD,and serum osteocalcin didn't decrease.BMD increased(P ＜0.05)and the predicted final height decreased in the observational group.Conclusion NYPF and TSRE Chinese herbal medicine sequential therapeutic scheme could effectively modulate the course of pubertal development,significantly prevent premature epiphyseal fusion and improve final height of idiopathic true precocious puberty female children patients.关键词
特发性真性性早熟/中药序贯治疗/滋阴泻火/益肾填精/青春发育进程/骨骼发育Key words
precocious puberty/Chinese herbal medicine sequential therapeutic scheme/nourishing yin purging fire/tonifying Shen replenishing essence/course of pubertal development/skeletal development引用本文复制引用
张亦群,蔡德培..滋阴泻火与益肾填精中药序贯治疗特发性真性性早熟女性患儿临床观察[J].中国中西医结合杂志,2018,38(1):33-37,5.基金项目
国家自然科学基金资助项目(No.30371820) （No.30371820）
