中国中西医结合杂志2018，Vol.38Issue(1)：50-53,4.DOI:10.7661/j.cjim.20170623.142
不同中医体质HIV/AIDS患者细胞免疫功能状态研究
Effect of Constitutions of Chinese Medicine on Immune Damage In HIV/AIDS Patients
摘要
Abstract
Objective To observe the effect of constitutions of Chinese medicine (CM) on immune damage process of HIV/AIDS patients,thus providing reference for treatment of HIV/AIDS with CM.Methods Sixty-eight HIV/AIDS patients' data were collected and analyzed.HIV infection patients were staged as acute period,asymptomatic period,and AIDS period by 2011 AIDS Diagnosis and Treatment Guidance in China.Their constitutions of CM were judged by Classification and Judgment of Constitutions of Chinese Medicine.CD4 +T lymphocyte count was detected using flow cytometry.Results Patients in acute stage of HIV infection (3 cases) were of single constitution (2 cases with Qi deficiency and 1 case with Yang deficiency).Complex constitution displayed during asymptomatic period (30 cases) and AIDS period (35 cases).The top 3 constitutions in asymptomatic period were qi deficiency constitution (12 cases),phlegm dampness constitution (7 cases),and damp heat constitution (7 cases) according to frequency of occurrence.The top 3 constitutions in AIDS stage were Qi deficiency constitution (15 cases),Yang deficiency constitution (8 cases),Yin deficiency constitution (7 cases) according to frequency of occurrence.Qi deficiency constitution occupied the top judged either by frequency of occurrence or higher score of differentiation.Patients with deficiency syndrome had lower CD4+T lymphocyte count,as compared with those with excess syndrome (P ＜0.01).CD4+T lymphocyte count was lower in Qi deficiency constitution than other deficiency constitutions (P ＜0.01).The range of CD4 +T lymphocyte count declined form asymptomatic period to AIDS period was larger in Qi deficiency constitution than in other deficiency constitutions (P ＜0.05).Conclusions Patients with different CM constitutions had various degrees of cellular immunedamage.Qi deficiency runs throughout the process of HIV/AIDS.Cellular immunity damage was more common seen in HIV/AIDS patients with deficiency constitution,especially with Qi deficiency constitution.关键词
HIV/AIDS/CD4+T淋巴细胞/中医体质Key words
human immunodeficiency virus/acquired immunodeficiency syndrome/CD4+T lymphocyte/constitution of Chinese medicine引用本文复制引用
俞冲,王忠成,顾玉玲..不同中医体质HIV/AIDS患者细胞免疫功能状态研究[J].中国中西医结合杂志,2018,38(1):50-53,4.基金项目
南通市科技局应用研究计划项目(No.BK2014082) （No.BK2014082）
