中药材2017，Vol.40Issue(7)：1687-1694,8.DOI:10.13863/j.issn1001-4454.2017.07.041
藏药多血康胶囊治疗HAPC的网络药理学机制研究
Network Pharmacology of Tibetan Medicine Duoxuekang Capsule in Treatment of High Altitude Polycythemia
摘要
Abstract
Objective:To explore the molecular mechanism of Tibetan medicine Duoxuekang capsule in the treatment of high altitude polycythemia(HAPC) by using network pharmacology.Methods:Firstly the chemical constituents of four flavor herbs (Phyllanthi Fructus,Rhodiolae Crenulatae Radix et Rhizoma,Hippophae Fructus,Zingiberis Rhizome) in Duoxuekang capsule were respectively screened by literature search and TCMSP database,then predictive analysis targets by PharmMapper server.Potential targets were submitted to MAS 3.0 database for target annotation and analysis.And pathway analysis would be performed with KEGG database.Finally,Cytoscape software was used to construct the “compounds-targets targets-pathway” network diagram of Duoxuekang capsule in treatment of HAPC.Results:Virtual experiments predicted 176 chemical constituents of Duoxuekang capsule,which involved 393 action targets.Finally 64 targets and 90 pathways related to Duoxuekang capsule anti-hypoxia,anti-oxidation and blood stasis was got.Conclusion:Duoxuekang capsule in treatment of HAPC is mainly through the regulation of the immune system,inflammatory sydtem,cardiovascular system and metabolic pathways,and may be involved in enhancing immune,improve blood coagulation and inflammatory reaction,regulate metabolism and other aspects.关键词
网络药理学/藏药/多血康胶囊/HAPC/作用机制Key words
Network pharmacology/Tibetan medicine/Duoxuekang capsule/High altitude polycythemia/Mechanism分类
医药卫生引用本文复制引用
王静,赵可惠,唐策,吕秀梅,降佣四朗,魏志成,张艺..藏药多血康胶囊治疗HAPC的网络药理学机制研究[J].中药材,2017,40(7):1687-1694,8.基金项目
国家自然科学基金(81603394,81503362) （81603394,81503362）
四川省教育厅省属高校科研创新团队建设计划(11TD004) （11TD004）
成都中医药大学科技发展基金(CGPY1503,030018002) （CGPY1503,030018002）
