川北医学院学报2017，Vol.32Issue(6)：831-834,860,5.DOI:10.3969/j.issn.1005-3697.2017.06.006
2型糖尿病患者胰岛β细胞功能、炎性因子与心功能的相关性研究
Study on the correlation between islet beta cell function, inflammatory factors and cardiac function in patients with T2DM
周莉 1王丛丛 2董砚虎 2张磊2
作者信息
- 1. 潍坊医学院临床医学院,山东潍坊261053
- 2. 青岛内分泌糖尿病医院,山东青岛266071
- 折叠
摘要
Abstract
Objective:To analyze the relationships between islet beta cell function,inflammatory factors and cardiac function in patients with type 2 diabetes mellitus (T2DM).Methods:Totally 1 879 T2DM patients were collected,including 1 515 cases first admitted in hospital and 364 cases repeatedly admitted in hospital.The prevalence of E/A ratio ＜ 1 in T2DM patients with different levels of islet beta cell function index (HOMA-β),hyper-sensitivity C reactive protein (hs-CRP),erythrocyte sedimentation rate (ESR) and tumor necrosis factor-α (TNF-α).The risk factors related to E/A ratio ＜ 1 was analyzed using Logistic regression analysis.For the patients repeatedly admitted in hospital,COX regression analysis was conducted.Results:There was statistical significance between the patients with normal cardiac diastolic function and those with abnormal cardiac diastolic function who first admitted in hospital in terms of gender,age,course of disease,waist circumference (WC),high-density lipoprotein cholesterol (HDL-C),hs-CRP,ESR and 3-hour C peptide (3 h-CP) (P ＜0.05 or P ＜0.01).The abnormal rates of cardiac diastolic function were not changed obviously among each group as increased HOMA-β and TNF-α level (P ＞ 0.05).The abnormal rates of cardiac diastolic function were on the rise as increased hs-CRP level and ESR,and there was statistical significance among each group regarding the abnormal rates of cardiac diastolic function (P ＜ 0.01).Logistic regression analysis revealed that both hs-CRP and ESR were influencing factors of abnormal cardiac diastolic function.COX regression analysis displayed that ESR had great impact on T2DM patients repeatedly admitted in hospital,and it could be a risk factor to predict abnormal cardiac diastolic function.Conclusion:The inflammatory infiltration and partial inflammatory factors in T2DM patients may be associated with the occurrence and progression of abnormal cardiac diastolic function,and may be have great impact on the patients' survival.关键词
2型糖尿病/胰岛β细胞功能/炎性因子/心功能Key words
Type 2 diabetes mellitus/Islet beta cell function/Inflammatory factors/Cardiac function分类
医药卫生引用本文复制引用
周莉,王丛丛,董砚虎,张磊..2型糖尿病患者胰岛β细胞功能、炎性因子与心功能的相关性研究[J].川北医学院学报,2017,32(6):831-834,860,5.
