川北医学院学报2017，Vol.32Issue(6)：864-866,870,4.DOI:10.3969/j.issn.1005-3697.2017.06.016
空腹和糖负荷后胰岛素抵抗评估与慢性肾脏病的关系探讨
Discussion on the relationship between insulin resistance assessment and chronic renal disease after fasting and sugar loading
摘要
Abstract
Objective:To compare the correlation between insulin resistance index and eGFR after fasting and glucose load in patients with non-diabetic chronic kidney disease (CKD).Methods:71 cases of CKD hospitalized patients were selected to evaluate eGFR according to the EPI formula corrected by the Chinese population.In accordance with the level of eGFR,patients were divided into three groups(eGFR ＜ 60 mL/min,60 mL/min ≤ eGFR ＜ 90 mL/min,eGFR ≥ 90mL/min).75 g glucose load test for patients was treated as laboratory examination.Insulin resistance was evaluated by insulin sensitivity index (ISI) and homeostatic model assessment of insulin resistance (HOMA-IR),respectively.Reduction of ISI or raise of HOMA-IR suggests insulin resistance.The clinical data of each group was compared,and the correlation between insulin resistance index and eGFR after the fasting and sugar load was analyzed.Results:The median eGFR was 81.70 mL/min,ISI decreased significantly with decreasing of GFR (P ＜ 0.001),and ISI was positively correlated with eGFR (r =0.523,P ＜0.001).The decrease of HOMA-IR with eGFR was not significantly changed,and there was no linear correlation with eGFR.Conclusion:In the CKD population,insulin resistance increased with the decrease of eGFR and ISI after sugar loading,while no significant correlation is found between HOMA-IR from the fasting source and eGFR.关键词
胰岛素抵抗/慢性肾脏病/肾小球滤过率Key words
Insulin resistance/Chronic kidney disease/eGFR分类
医药卫生引用本文复制引用
张寅,周亦伦,封怡多,丁霞,王冬雪,张常勤,吴昱,龚勇..空腹和糖负荷后胰岛素抵抗评估与慢性肾脏病的关系探讨[J].川北医学院学报,2017,32(6):864-866,870,4.基金项目
北京市卫生局项目(2014-3-021) （2014-3-021）
