川北医学院学报2017，Vol.32Issue(6)：911-914,4.DOI:10.3969/j.issn.1005-3697.2017.06.030
2型糖尿病患者血清25-羟维生素D水平对糖尿病周围神经病变的影响
Influence of serum 25-hydroxy vitamin D level on diabetic peripheral neuropathy in patients with type 2 diabetes mellitus
席建花 1张磊 2高维国 2张薛 2董砚虎2
作者信息
- 1. 潍坊医学院临床医学院,山东潍坊261053
- 2. 青岛内分泌糖尿病医院内分泌科,山东青岛 266071
- 折叠
摘要
Abstract
Objective:To explore the level of serum 25-hydroxy vitamin D (25 (OH)D) in patients with type 2 diabetes mellitus (T2DM) and its influence on diabetic peripheral neuropathy (DPN).Methods:A total of 367 patients with T2DM were selected and divided into non-DPN group (NDPN group,n =192) and DPN group (n =175) based on the presence of DPN.General data and biochemical index levels were analyzed between two groups.Results:DPN group was evidently higher in patients' age,glycosylated hemoglobin (HbA 1 c) level,diabetic course,and homeostatic model assessment-insulin resistance (HOMA-IR) (P ＜ 0.05),but was notably lower in serum level of 25 (OH)D and bone density than NDPN group (P ＜ 0.05).Pearson correlation analysis showed age,diabetic course and HbA1c level were in positive association with DPN while HOMA-IR and 25 (OH) D in negative association(r =-0.302,P =0.000).Age,diabetic course and 25(OH) D level were influencing risk factors for the occurrence of DPN in patients with T2DM.Conclusion:Serum 25 (OH) D deficiency is closely associated with the occurrence of DPN as it can increase the morbidity of DPN.And the risk of DPN is increased in patients with T2DM with the increases of age,disease course,HbA1C and HOMA-IR.关键词
2型糖尿病/25-羟维生素D/周围神经病变Key words
Type 2 diabetes mellitus/25-hydroxy vitamin D/Diabetic peripheral neuropathy分类
医药卫生引用本文复制引用
席建花,张磊,高维国,张薛,董砚虎..2型糖尿病患者血清25-羟维生素D水平对糖尿病周围神经病变的影响[J].川北医学院学报,2017,32(6):911-914,4.
