摘要
Abstract
Objective:To evaluate the application value of thymosin in the clinical treatment of acute exacerbation of chronic obstructive pulmonary disease (AECOPD).Methods:A total of 75 patients with AECOPD were randomly divided into experiment group (n =38) and control group (n =37).Both groups were treated with routine therapies for chronic obstructive pulmonary disease (COPD),on which basis experiment group was added with intravenous injection of thymosin,for totally 14 d.Therapeutic efficacy was compared between two groups,and the changes of blood-gas analytic indexes,lung function indexes and cellular immunity indexes were observed before and after treatment.Results:The total response rate was 92.11％ in experiment group,evidently higher than the 72.97％ in control group (P ＜ 0.05).After treatment,arterial partial pressure of oxygen (PaO2,),arterial partial pressure of carbon dioxide (PaCO2),forced expiratory volume in one second (FEV1),and the ratio of FEV1 and forced vital capacity (FEV1/FVC) were improved notably,which changed more significantly in experiment group than those in control group (P ＜ 0.05 or P ＜ 0.01).After treatment,levels of CD4 + and CD4 +/CD8 + increased prominently while level of CD8 + decreased apparently than treatment before,which changed more significantly in experiment group than those in control group (P ＜ 0.05 or P ＜ 0.01).Conclusion:Application of thymosin on the basis of routine treatment can effectively improve the clinical symptoms and enhance the cellular immunity function of patients with AECOPD.关键词
胸腺肽/慢性阻塞性肺疾病急性加重期/细胞免疫/肺功能Key words
Thymosin/Acute exacerbation of chronic obstructive pulmonary disease/Cellular immunity/Lung function分类
医药卫生
