重庆医学2018，Vol.47Issue(2)：164-166,3.DOI:10.3969/j.issn.1671-8348.2018.02.006
CXCL10、CXCR3及T细胞亚群在进展期白癜风患者外周血中的表达及复方中药对其影响
Expression of CXCL10 ,CXCR3 and T cell subsets in peripheral blood and effect of compound Chinese medicine on it in patients with advanced vitiligo
摘要
Abstract
Objective To detect the expression levels of peripheral blood CXCL10 and its receptor CXCR3 and T cell subsets in of the patients with advanced vitiligo and the influence of compound Chinese medicine on it.Methods Flow cytometry was used to detect the cellular proportions of peripheral blood T cell subsets,ELISA was employed to quantify serum CXCL10 and CXCR3 expression levels before and after treatment.Results After 1 month of taking Chinese medicine,the proportions of CD3+ CD4+ cells and CD3+ CD8+ cells were increased compared before treatment(P＜0.05).The expression level of peripheral serum CXCL10 before treatment was significantly increased compare with the healthy control group(P＜0.01),and the CXCL10 level after treatment was decreased significantly compared with that before treatment(P＜0.05).The expression level of peripheral serum CXCR3 was significantly increased compared with the healthy control group(P＜0.05),while which after treatment was still significantly higher than that in the healthy control group(P＜0.05).Conclusion CXCL10,CXCR3 and T cell subsets proportion may be involved in the pathogenesis of vitiligo.The compound Chinese medicine used in this study plays the curative effect possibly by regulating T cell subsets and expression levels of CXCL10 and CXCR3.关键词
白癜风/中草药/趋化因子CXCL10/受体,CXCR3/T淋巴细胞亚群Key words
vitiligo/drugs, chinese herbal/chemokine CXCL10/receptors, CXCR3/T-lymphocyte subsets分类
医药卫生引用本文复制引用
邓莉,江雪,王禹毅,史丙俊,刘洋,徐伟,刁庆春,郑文豪..CXCL10、CXCR3及T细胞亚群在进展期白癜风患者外周血中的表达及复方中药对其影响[J].重庆医学,2018,47(2):164-166,3.基金项目
国家自然科学基金(81503588) （81503588）
重庆市卫生和计划生育委员会基金项目(ZY20140251) （ZY20140251）
重庆市科技委员会基础与前沿研究计划(cstc2015jcyjA10113). （cstc2015jcyjA10113）
