重庆医学2018，Vol.47Issue(2)：206-208,3.DOI:10.3969/j.issn.1671-8348.2018.02.020
脐带间充质干细胞输注治疗难治性类风湿关节炎的疗效及安全性初探
Priliminary study on efficacy and safety of umbilical cord mesenchymal stem cells infusion for treating refractory rheumatoid arthritis
高乐女 1钟兵 1王勇 1陈雪猛 1陈珏蓉 1方勇飞1
作者信息
- 1. 陆军军医大学/第三军医大学西南医院中西医结合科·风湿免疫中心,重庆400038
- 折叠
摘要
Abstract
Objective To explore the efficacy and safety of umbilical cord mesenchymal stem cells(UC-MSCs) infusion in treating refractory rheumatoid arthritis(RA).Methods Four cases of refractory RA and invalid by improving disease condition and anti-rheumatic drugs in this hospital from December 2014 to November 2015 underwent once UC-MSCs suspension intravenous infusion after signing the informed consent.The cells number was 1 × 106 per kg.We evaluated the tender and swollen joints number,erythrocyte sedimentation rate(ESR),C-reactive protein(CRP),28-joint disease activity score(DAS28),visual analog scale(VAS)pain score and related safety indices were compared between before and after infusion.Results After infusion treatment in 3 cases,the tender and swollen joints number,ESR and DAS28(4) score were significantly improved,but another case was ineffective.No anaphylaxis,rejection reaction or adverse events occurred in all cases and no abnormal change was found in routine blood,liver and kidney function.Conclusion The UC-MSCs infusion is has good safe for treating refractory RA and improves the disease condition to some extent.关键词
间质干细胞/关节炎,类风湿/治疗效果/安全Key words
mesenchymal stem cells/arthritis, rheumatoid/treatment outcome/safety分类
医药卫生引用本文复制引用
高乐女,钟兵,王勇,陈雪猛,陈珏蓉,方勇飞..脐带间充质干细胞输注治疗难治性类风湿关节炎的疗效及安全性初探[J].重庆医学,2018,47(2):206-208,3.
