摘要
Abstract
Objective To observe the clinical efficacy of mastoid subperiosteal injection with methylprednisolone on sudden deafness. Methods Seventy-eight patients with sudden deafness were randomly divided into observation group and control group,with 39 cases in each group. Both groups were treated with mecobalamin injection,vitamin B1 injection and intravenous drip of Ginkgo biloba extract,and on the basis of the conventional therapy above,the observation group was given mastoid subperiosteal injection with methylprednisolone at retroauricular groove,while the control group with dexamethasone sodium phosphate. The clinical efficacy,pure tone threshold,indices of complete blood test,levels of serum endothelin(ET),nitric oxide(NO) and homocysteine(Hcy) before and after treatment,and incidence of adverse reactions were compared between the two groups. Results The total effective rates of the observation group and the control group were 92. 3％ and 74. 4％,respectively,and the efficacy of the observation group was better than that of the control group(P<0. 05). After treatment, the pure tone threshold,PLT count and the levels of serum ET and Hcy were lower,but the level of NO was higher in the observation group compared to the control group(P <0. 05),and there was no significant difference in the WBC count,RBC count or incidence rate of adverse reactions between the two groups(P>0. 05). Conclusion The mastoid subperiosteal injection with methylprednisolone based on the conventional therapy has definite effects on sudden deafness,which can effectively improve the hearing,and it is safe and reliable.关键词
突发性耳聋/甲泼尼龙琥珀酸钠/乳突骨膜下注射Key words
Sudden deafness/Methylprednisolone/Mastoid subperiosteal injection分类
医药卫生
