解放军医药杂志2018，Vol.30Issue(1)：23-26,4.DOI:10.3969/j.issn.2095-140X.2018.01.006
GDP方案化疗治疗弥漫大B细胞淋巴瘤的效果及预后分析
Efficacy and Prognosis of GDP Chemotherapy Plan in Treatment of Diffuse Large B-cell Lymphoma
摘要
Abstract
Objective To investigate effect of Gemcitabine+Dexamethasone+Cisplatin ( GDP) chemotherapy plan in treatment of diffuse large B-cell lymphoma and its effect on prognosis. Methods A total of 68 patients with dif-fuse large B-cell lymphoma admitted during January 2012 and December 2014 were divided into control group ( n=30 ) and observation group ( n=38 ) according to therapeutic methods. Control group was treated with DICE chemotherapy plan on the basis of routine treatment, while observation group was treated with GDP chemotherapy plan on the basis of routine treatment. After treatment, short-term curative effect and long-term prognosis were compared, and related factors affecting prognosis were analyzed in two groups. Results The total effective rate was significantly higher in observation group than that in control group (P<0. 05). In observation group, thrombosis rate was significantly higher, while inci-dence rates of baldness, neuropathy and gastritis were significantly lower than those in control group (P<0. 05). At the end of 2 years of follow-up, no event and progression-free survival rates in observation group were significantly higher than those in control group (P<0. 05). Ann Arbor stage, age, marrow infiltration, international prognosis index (IPI) score and chemotherapy plan were related factors affecting prognosis (P<0. 05). Conclusion GDP chemotherapy plan may significantly improve short-term curative effect and prolong long-term survival time with good safety in treatment of patients with diffuse large B-cell lymphoma.关键词
淋巴瘤,大B细胞,弥漫性/抗肿瘤联合化疗方案/治疗结果/预后Key words
Lymphoma,large B-cell,diffuse/Antineoplastic combined with chemotherapy protocols/Treatment outcome/Prognosis分类
医药卫生引用本文复制引用
李业成,何光翠,刘芳,吕素娟,成晓敏,张珊,邓锐,苏毅..GDP方案化疗治疗弥漫大B细胞淋巴瘤的效果及预后分析[J].解放军医药杂志,2018,30(1):23-26,4.基金项目
四川省科技计划项目(2014JY0149) （2014JY0149）
