解放军医药杂志2018，Vol.30Issue(1)：31-33,37,4.DOI:10.3969/j.issn.2095-140X.2018.01.008
非小细胞肺癌患者血浆和组织中尾加压素Ⅱ的表达及临床意义
Expressions and Significances of Urotensin Ⅱ in Plasma and Tissues of Patients with Non-small Cell Lung Cancer
摘要
Abstract
Objective To investigate Urotensin-Ⅱ( U Ⅱ) expressions in plasma and lung cancer tissues by sur-gical resection of patients with non-small cell lung cancer ( NSCLC) . Methods A total of 75 NSCLC tissues and 33 in-flammatory pseudotumour tissues in lung by surgical resection during January 2009 and January 2011 were collected, and correlations between U Ⅱ expression with NSCLC pathological types and TNM stage were analyzed. U Ⅱ contents in 75 NSCLC tissues, 38 benign lesions and 30 healthy plasma samples were detected, and correlations between U Ⅱ contents with NSCLC pathological types and whether having distant metastasis or not were also analyzed. Results U Ⅱ expression level in plasma of NSCLC was significantly higher than those in control and benign lesions groups, and plasma U Ⅱ level had a certain correlations with pathological types and distant metastasis (P<0. 05, P<0. 01). UⅡgenerally existed in cytoplasm of NSCLC cells especially in adenocarcinoma cells. There were closely correlations between UⅡexpression with pathological types and TNM stage (P<0. 05). UⅡ expressions were basically the same trend in plasma and cancer tis-sues of NSCLC patients. Conclusion Malignant abilities of U Ⅱ growth and metastasis in NSCLC cells increase signifi-cantly, and therefore it can be used as a molecular maker to monitoring malignant growth of lung adenocarcinoma.关键词
癌,非小细胞肺/尾加压素Ⅱ/放射免疫测定/免疫组化Key words
Carcinoma,non-small-cell lung/Urotensin Ⅱ/Radioimmunoassay/Immunohistochemistry分类
医药卫生引用本文复制引用
高鸿敏,杜玉国,高进辽..非小细胞肺癌患者血浆和组织中尾加压素Ⅱ的表达及临床意义[J].解放军医药杂志,2018,30(1):31-33,37,4.基金项目
国家自然科学基金(3037632) （3037632）
