解放军医药杂志2018，Vol.30Issue(1)：46-48,3.DOI:10.3969/j.issn.2095-140X.2018.01.012
水通道蛋白1,3在变应性鼻炎大鼠鼻黏膜的表达及促鼻内腺体分泌的研究
Aquaporin 1,3 Expressions in Nasal Mucosa Tissues of Rats with Allergic Rhinitis and Promotion of Nasal Glands Secretion
摘要
Abstract
Objective To investigate aquaporin 1 and 3 (AQP1,3) expressions in nasal mucosa tissues of rats with allergic rhinitis and its action mechanism of promoting nasal glands secretion. Methods A total of 40 healthy rats were randomly divided into control group and experimental group ( n=20 for each group) . Control group was intraperito-neally injected with the same volume of physiological saline, while rats in experimental group were established allergic rhinitis models. Serum ion concentration, AQP1,3 expressions in nasal mucosa tissues and secretion volumes of nasal glands were detected in two groups. Results Compared with those in control group, serum Ca2+ and K+ concentrations were significantly decreased, while Na+ concentration was significantly increased in experimental group (P <0. 01). AQP1,3 values of expression areas and secretion volumes of nasal glands in experimental group were significantly in-creased than those in control group (P<0. 05). Conclusion AQP1,3 expressions in nasal mucosa tissues of rats with allergic rhinitis are increased, and the increased AQP1,3 expressions may be affected secretion volumes of nasal glands.关键词
变应性鼻炎/水通道蛋白1,3/鼻内腺体/大鼠Key words
Allergic rhinitis/Aquaporin 1,3/Nasal glands/Rats分类
医药卫生引用本文复制引用
许敏达..水通道蛋白1,3在变应性鼻炎大鼠鼻黏膜的表达及促鼻内腺体分泌的研究[J].解放军医药杂志,2018,30(1):46-48,3.基金项目
浙江省医药卫生科技计划项目(2015DTA001) （2015DTA001）
