解放军医药杂志2018，Vol.30Issue(1)：60-63,4.DOI:10.3969/j.issn.2095-140X.2018.01.016
子痫前期患者氧化应激、炎性反应及血管内皮损伤的临床研究
A Clinical Study on Oxidative Stress, Inflammatory Reaction and Vascular Endothelial Injury in Preeclampsia Patients
摘要
Abstract
Objective To investigate main pathogenesis of preeclampsia patients. Methods A total of 40 pregnant women with gestational hypertension, 40 pregnant women with preeclampsia and 40 pregnant women with severe preeclampsia during August 2013 and June 2017 were recruited in this study, and other 40 normal pregnant women were selected as control group, and related levels of serum factors were analyzed in four groups. Results In control, gesta-tional hypertension, preeclampsia and severe preeclampsia groups, serum paraoxonase-1 ( PON-1 ) and adiponectin ( APN) and high density lipoprotein cholestorol ( HDL-L ) levels were gradually decreased, while lipoprotein related phospholipase A2 (Lp-PLA2), interleukin-6 (IL-6), tumor necrosis factor-α(TNF-α) and C-reactive protein (CRP), total cholesterol ( TC ) , triglyceride ( TG ) and low density lipoprotein cholestorol ( LDL-C ) levels were gradually in-creased (P<0. 05). Conclusion Oxidative stress, inflammatory reaction and vascular endothelial injury may be all re-lated to pathogenesy and progression of preeclampsia, and treatments such as appropriate anti-infection and protecting blood vessels are also key measures in treatment of preeclampsia besides of controlling blood pressure.关键词
子痫前期/氧化应激/炎性反应/血管内皮损伤Key words
Preeclampsia/Oxidative stress/Inflammatory reaction/Vascular endothelial injury分类
医药卫生引用本文复制引用
史丹丹,王勇,郭君君,王娜,白玉来,王学珍,史亚玲..子痫前期患者氧化应激、炎性反应及血管内皮损伤的临床研究[J].解放军医药杂志,2018,30(1):60-63,4.基金项目
河北省科学技术厅科技支撑项目(20171305) （20171305）
