河北医学2018，Vol.24Issue(1)：11-16,6.DOI:10.3969/j.issn.1006-6233.2018.01.003
KW-2478对肿瘤细胞增殖作用的影响
Influence of KW-2478 on the Proliferation of Tumor Cells
摘要
Abstract
Objective:To study the effect on proliferation of KW-2478 to Eca109 and KYSE-150 e-sophageal cancer cell line, SGC-7901 gastric cancer cell line, HepG2 hepatoma cell line and MCF-7 breast cancer cell in vitro. And to observe the effect of KW-2478 to HL-7702 normal hepatocytes. Methods:HL-7702, Eca109, KYSE-150, SGC-7901, MCF-7 and HepG2 cell lines were cultured in vitro, give different concentrations of KW-2478, MTT assay test cell proliferation after 24h and 48h. Results:After 24h and 48h different concentrations of KW-2478 to the tumor cells, the proliferation of five tumor cells were reduced in dose-dependent and time-dependent, and showed dose and time interaction on Eca109 cells and HepG2 cells, but HL-7702 was not significantly affected. Conclusion:KW-2478 have inhibitory effect to Eca109, KYSE-150, SGC-7901, MCF-7 and HepG2 cells, and had no significant effect on the proliferation of HL-7702 normal hepatocytes.关键词
KW-2478/MTT/增殖/肿瘤细胞Key words
KW-2478/MTT/Proliferation/Tumor cells引用本文复制引用
常晓敏,王建平,赵学荣,肖丽君,赵恩宏,任聪,白文武..KW-2478对肿瘤细胞增殖作用的影响[J].河北医学,2018,24(1):11-16,6.基金项目
河北省病原生物学重点学科 （）
承德医学院免疫学重点学科 （）
河北省教育厅重点项目,(编号:ZD2014003) （编号:ZD2014003）
