河北医学2018，Vol.24Issue(1)：20-26,7.DOI:10.3969/j.issn.1006-6233.2018.01.005
瑞芬太尼复合麻醉对开腹结肠癌手术术后患者IL-6 MDA及SOD水平影响
Effects of Remifentanil Combined Anesthesia on IL-6 MDA and SOD Levels in Patients with Open Colon Cancer Surgery
摘要
Abstract
Objective:To investigate the effect of remifentanil combined anesthesia on the levels of interleukin-6 ( IL-6 ) , malondialdehyde ( MDA ) and superoxide dismutase ( SOD ) in postoperative patients undergoing open colon cancer surgery. Methods:From March 2015 to March 2017 in our hospital, 68 cases of open colorectal cancer patients with operation were selected as the research object. According to the random number table method the patients were divided into two groups. The study group underwent remifentanil and propofol anesthesia, the control group underwent sufentanil and propofol anesthesia. The levels of IL-6, IL-8, CRP , MDA, SOD and adverse reaction rates of the two groups before and after anesthesia induction, 1h af-ter operation, 1D after operation and 3D after operation were compared. Results:There was no significant difference in the levels of IL-6, IL-8, CRP, MDA and SOD in the two groups before induction (P>0.05). After operation, the levels of IL-6, IL-8 and CRP in the two groups were significantly higher than those be-fore the operation ( P<0.05) . One hour, oneday and three days after operation, The levels of IL-6, IL-8 and CRP in the study group were significantly lower than those in control group (P<0.05). MDA was increased and SOD decreased in both group ( P<0.05) . Compared between groups, there was no statistical difference in postoperative of one hour and one day ( P>0.05) . The MDA level of 3D after operation was lower than that of control group, while SOD level was higher than that of control group (P<0.05). There was no significant difference in the rate of adverse reaction between the two groups (χ2 =0. 327, P>0. 05 ) . Conclusion:Remifentanil combined anesthesia applied to open colon cancer surgery can significantly reduce the levels of IL-6, IL-8, CRP , MDA, and increase the level of SOD, which significantly reduce the postoperative inflam-matory and oxidative stress response.关键词
结肠癌/瑞芬太尼/复合麻醉/白细胞介素-6/氧化应激Key words
Colon cancer/Remifentanil/Combined anesthesia/Interleukin -6/Oxidative stress引用本文复制引用
计鹏,姚帆,曹波,李明强,吴树宁,周立文,李才顺..瑞芬太尼复合麻醉对开腹结肠癌手术术后患者IL-6 MDA及SOD水平影响[J].河北医学,2018,24(1):20-26,7.基金项目
湖北省自然科学基金资助项目,(编号:2013CFB465) （编号:2013CFB465）
