河北医学2018，Vol.24Issue(1)：26-30,5.DOI:10.3969/j.issn.1006-6233.2018.01.006
食管癌中肝细胞生长因子及其受体的表达与淋巴管生成和淋巴结转移的关系
The Expression of HGF and its Receptor c-met in Human Esophageal Carcinoma and the Relationship to Lymphangiogenesis and Lymphatic Metastasis of EC
摘要
Abstract
Objective:To determin the expression of HGF and its receptor c-met in human esophageal carcinoma and to investigate the relationship between HGF and its receptor with lymphangiogenesis and lym-phatic metastasis of EC. Method:Immunohistochemical staining was used to examine expression of HGF and c-met in 30 cases of NM and 70 cases of EC tissues.The microlymphatic density (LMVD) in esophageal carci-noma was calculated by D2-40 as the specific marker of lymphatic endothelium. Results:Expression of HGF and c-met in EC showed significantly higher than that in NM, and they were positively correlated with lym-phangiogenesis and lymphatic metastasis of EC. Conclusion:The overexpression of HGF and c-met may play an important role in lymphangiogenesis and lymphatic metastasis of EC.关键词
食管癌/肝细胞生长因子/微淋巴管密度Key words
Esophageal carcinoma/HGF/LMVD引用本文复制引用
赵杨,刘莎莎,徐树雷,申兴斌..食管癌中肝细胞生长因子及其受体的表达与淋巴管生成和淋巴结转移的关系[J].河北医学,2018,24(1):26-30,5.基金项目
承德市科学技术研究与发展计划,(编号:20132049) （编号:20132049）
