河北医学2018，Vol.24Issue(1)：34-38,5.DOI:10.3969/j.issn.1006-6233.2018.01.008
肾癌患者血清VHL HIF-1αHIF-2α 水平变化及意义
The Level Changes and Significance of Serum VH HIF-1αand HIF-2αLevels in Patients with Kidney Cancer
摘要
Abstract
Objective:To research the changes and significance of serum von hippel-lindau ( VHL ) , hypoxia-inducible factor ( HIF)-1α and HIF-2α in patients with renal cancer. Method:45 cases of renal carcinoma were collected from January 2015 to April 2016 as the renal cell cancer group, and at the same time the collection of healthy persons as control group, serum VHL, HIF-1αand HIF-2αlevel of two groups were examined;The maximum diameter of renal cancer patients was measured; Patients with renal cell carcinoma were followed up for 6 months, observed and recorded the recurrence patients. Results:The level of serum VHL in renal cancer group decreased significantly compared with that in control group, while levels of HIF-1α and HIF-2αwere obviously higher( P<0.01) . Expression of serum VHL, HIF-1αand HIF-2αwas not related to age and sex in renal carcinoma ( P>0. 05) ,while there was significantly correlated with pathological grade, clinical stages, diameter of cancer site and lym-phatic metastasis ( P<0.01) . Level of serum VHL in recurrent cases was obviously lower, while levels of HIF-1αand HIF-2αwere obviously higher than non-re-current cases( P< 0.05,P<0.01) . Conclusion:Levels of serum VHL, HIF-1α and HIF-2α are correlated significantly with pathological grade, clinical stages, size of carcinoma and lymphatic metastasis, which indi-cates indexes mentioned above could be play an important role in the occurrence and development of clear cell renal carcinoma.关键词
肾癌/VHL基因/缺氧诱导因子-1α/缺氧诱导因子-2αKey words
Renal carcinoma/VHL/HIF-1α/HIF-2α引用本文复制引用
史春夏,李忠心,刘永泉,张会敏..肾癌患者血清VHL HIF-1αHIF-2α 水平变化及意义[J].河北医学,2018,24(1):34-38,5.基金项目
北京市自然科学基金,(编号:6832236) （编号:6832236）
