河北医学2018，Vol.24Issue(1)：135-139,5.DOI:10.3969/j.issn.1006-6233.2018.01.036
光动力法配合激素治疗对增生性瘢痕患者VSS评分改善效果及p-STAT3 Egr-1表达的影响
Effect of Photodynamic Therapy Combined with Hormone Therapy on the Improvement of VSS Score and Expression of p-STAT3 and Egr-1 in Patients with Hypertrophic Scars
摘要
Abstract
Objective:To investigate the effect of photodynamic therapy combined with hormone therapy on the improvement of VSS score and the expression of p-STAT3 and Egr-1 in patients with hypertrophic scars. Method:A total of 124 patients with hypertrophic scars treated in our hospital from January 2014 to Ju-ly 2016 were randomly divided into control group and observation group, with 62 patients in each group. The control group was treated with glucocorticoid alone. The observation group was treated with photodynamic ther-apy on the basis of the control group. The VSS score and the curative effect were evaluated and analyzed before and after treatment. The levels of p- STAT3, Egr-1 expression. Results:After 2 months of treatment, the VSS score of the observation group was significantly lower than that of the control group ( P <0.05) . The treat-ment efficiency of the observation group was significantly higher than that of the control group ( P <0.05) . Af-ter treatment, the levels of p-STAT3 and Egr-1 in both groups were significantly decreased ( P <0.05) , and the two indexes in the observation group were significantly lower than those in the control group (P <0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P> 0.05). Conclusion:The combined use of photodynamic therapy and glucocorticoid can effectively inhibit the expres-sion of p-STAT3 and Egr-1 in patients with hypertrophic scar and reduce the score of VSS, which has better therapeutic effect and has certain safety.关键词
光动力/糖皮质激素/增生性瘢痕/p-STAT3/Egr-1Key words
Photodynamic/Glucocorticoid/Hypertrophic scars/p-STAT3/Egr-1引用本文复制引用
宁金斌,冯剑..光动力法配合激素治疗对增生性瘢痕患者VSS评分改善效果及p-STAT3 Egr-1表达的影响[J].河北医学,2018,24(1):135-139,5.基金项目
陕西省卫生厅科研基金项目,(编号:2014JM43264) （编号:2014JM43264）
