河北医学2018，Vol.24Issue(1)：152-155,4.DOI:10.3969/j.issn.1006-6233.2018.01.040
苦参碱预处理对大鼠脑缺血再灌注神经细胞凋亡及Bcl-2 Bax蛋白表达的影响
Effects of Matrine Pretreatment on Nerve cell Apoptosis and Expression of Bax and Bcl-2 Protein in rats with Cerebral Ischemia and Reperfusion
摘要
Abstract
Objective:To observe the effects of matrine pretreatment on the apoptosis of nerve cells and the expression of Bcl-2 and Bax after cerebral ischemia and reperfusion in the brain. Methods:60 healthy SD rats were randomly divided into 6 groups, namely sham group, model group, matrine group ( 4, 8, 16 mg/kg), edaravone group (1 mg/kg). The cerebral ischemia reperfusion injury model was established by suture method in rats. Then neuro-behavior was scored in different time, brain cell apoptosis was determined and the expression of Bax and Bcl-2 were examined. Results:Compared by the model group, rats in matrine pretreat-ment group showed better neurobehavioral score ( P<0.05) , lower brain cell apoptosis rate ( P<0.05) , signifi-cantly higher expression of bcl-2 protein ( P<0.01) and lower expression of Bax protein ( P<0.05) . Conclu-sion:Matrine shows a neuro-protective role on cerebral ischemia and reperfusion injury in rats and it enhances the expression of Bcl-2 protein and inhibits the expression of Bax protein.关键词
苦参碱/脑缺血再灌注/凋亡率/Bcl-2/BaxKey words
Matrine/Cerebral ischemia reperfusion/Apoptosis rate/Bcl-2/Bax引用本文复制引用
赵艳武,才春华,姜松,王莹,胡久丽,李代晓,肖旭..苦参碱预处理对大鼠脑缺血再灌注神经细胞凋亡及Bcl-2 Bax蛋白表达的影响[J].河北医学,2018,24(1):152-155,4.基金项目
承德市科学技术研究与发展计划项目,(编号:20122128) （编号:20122128）
