河北医学2018，Vol.24Issue(1)：167-170,4.DOI:10.3969/j.issn.1006-6233.2018.01.044
Th1/Th2细胞因子在初发型溃疡性结肠炎治疗前后的血清水平变化
The Changes of Serum Levels of Th1/Th2 Cytokines before and after the Treatment of Active Ulcerative Colitis
摘要
Abstract
Objective:To observe the changes of serum levels of Th1/Th2 cytokin before and after the treatment of ulcerative colitis ( UC) . Methods:58 patients with active UC were selected into UC group while 58 healthy persons as control group. The expression of IL-2、IFN-γ、IL-4、IL-10 in serum were measured at the 3 different time points:before treatment, 3 months and 12 months after treatment. Results:Before treat-ment, the expression of IFN-γ、IL-10 in serum decreased but IL-4 increased in UC group, with statistical differences ( P<0.05) . 3 months and 12 months after treatment, the expression of IFN-γ in UC group was lower significantly than control group, but no statistical difference was found in UC group. The expression of IL-4 was higher significantly than control group, especially at the time point of 12 months after treatment ( P<0. 05) . The expression of IL-10 was lower than control group, but it increased significantly at the time point of 12 months after treatment ( P<0.05) . There was no statistical difference in the expression of IL-2 between the two groups ( P>0.05) . Conclusion:It was suggested that the expression of IFN-γ decreased and IL-4 in-creased in serum during active UC, would inhibit the Th1 cells immune response to limit inflammatory process.During the remission of UC, the expression of IL-4 decreased and IL-10 increased would keep the balance of Th1/Th2 cells gradually.关键词
溃疡性结肠炎/Th1/Th2细胞因子/炎症Key words
Ulcerative colitis/Th1/Th2 cytokines/Inflammation引用本文复制引用
王玮,谭玉婷,罗丹,李启祥,尹合坤..Th1/Th2细胞因子在初发型溃疡性结肠炎治疗前后的血清水平变化[J].河北医学,2018,24(1):167-170,4.基金项目
2015年江门市科技计划项目,(编号:江科[ 2015] 73号) （编号:江科[ 2015] 73号）
