河北医学2018，Vol.24Issue(1)：170-174,5.DOI:10.3969/j.issn.1006-6233.2018.01.045
鼠神经生长因子联合腺苷钴胺对糖尿病周围神经病变患者血清ESM-1 ET-1 MBP Hcy的影响研究
Effects of Mouse Nerve Growth Factor Combined with Adenosine Cobalt on Serum ESM-1, ET-1, MBP and Hcy in Patients with Diabetic Peripheral Neuropathy
摘要
Abstract
Objective:To investigate the effects of mouse nerve growth factor combined with adenosine cobalt on diabetic peripheral neuropathy in patients with clinical efficacy and serum on endothelial cell specific molecule -1 (ESM-1), endothelin -1 (ET-1), myelin basic protein (MBP) and homocysteine (Hcy) lev-el of influence. Methods:90 patients of diabetic peripheral neuropathy sdmitted in our hospital from April 2016 to July 2017 were selected as research objects. The two groups were treated with Mouse Nerve Growth Factor for Injection after their examination. On this basis, the observation group added adenosine cobalamin in-jection. Dynamic monitoring and analysis of clinical efficacy of two groups of patients before and after treat-ment, TSS ( neuropathy symptoms questionnaire) , TCSS ( Toronto clinical scoring system) and VAS ( visual analogue scale) score, observation of the two groups of patients with serum ESM-1, ET-1, MBP, Hcy level and nerve conduction velocity. Results:After treatment, the total effective rate of the observation group was 86.67％ (39/45) superior to that of the control group (68.89％ (31/45) (P < 0.05). The scores of TSS, TCSS and VAS in the observation group were all lower than those in the control group ( P < 0.05) . The serum levels of ESM-1, ET-1, MBP and Hcy in the observation group were lower than those in the control group ( P< 0.05) . The MNCV and SNCV of the tibial nerve and median nerve in the observation group increased signif-icantly, and the conduction velocity was better than that of the control group (P < 0.05). Conclusion:The combination of mouse nerve growth factor and adenosine cobalamin can improve the clinical efficacy and nerve conduction velocity, and decrease serum ESM-1, ET-1, MBP and Hcy levels, as well as TSS, TCSS and VAS scores.关键词
鼠神经生长因子/腺苷钴胺/糖尿病周围神经病变Key words
Mouse nerve growth factor/Adenosine cobalt/Diabetic peripheral neuropathy/ESM-1/ET-1/MBP/Hcy引用本文复制引用
桑谊荃,孙妍,王犇..鼠神经生长因子联合腺苷钴胺对糖尿病周围神经病变患者血清ESM-1 ET-1 MBP Hcy的影响研究[J].河北医学,2018,24(1):170-174,5.基金项目
徐州市科技局项目,(编号:XZZDY1501) （编号:XZZDY1501）
