四川大学学报（医学版）2018，Vol.49Issue(1)：59-64,6.
AXIN和MACC1蛋白在胃癌组织中的表达及其临床意义
Expression of AXIN and MACC1 in Gastric Carcinoma and Its Clinical Significance
摘要
Abstract
Objective To investigate the expression of axis inhibition protein (AXIN) and metastasisassociated in colon cancer-1 (MACC1) in gastric carcinoma and their relationship to the clinicopathologic characteristics.Methods Expressions of AXIN and MACC1 proteins were examined by immunohistochemistry containing 100 specimens of gastric tissues (gastric carcinoma group) and 60 specimens of normal gastric mucosa tissues (control group,the nearby tissues of the excised specimen of gastric cancer patients,from the tumor of the gastric cancer ＞5.0 cm,and confirm that there were no cancer cells).Results The positive rates of AXIN and MACC1 proteins in gastric carcinoma and the control tissues were 37.0％ vs.83.3％ and 58.0％ vs.6.7％,respectively.The difference were significant between the two groups (both P＜0.05).The expressions of AXIN and MACC1 proteins were significantly related with grades of tumor,depth of invasion,lymph node metastasis,and Duke stages (P＜ 0.05).Spearman analysis showed that there was a negative relationship between the AXIN expression and MACC1 expression (r=-0.355,P＜0.05).Kaplan-Meier survival analysis and log-rank single factor analysis showed that AXIN and MACC1 protein expressions were related to the 5-year survival rate of patients (both P＜0.05).Cox regression analysis showed that the positive expression of AXIN and the negative expression MACC1 protein,and Duke stages (Ⅲ-Ⅳ) were the independent prognostic factors of gastric carcinoma.Conclusion The expressions of AXIN and MACC1 proteins are related to the prognosis of gastric carcinoma patients,and are involved in the invasion and metastasis of gastric carcinoma.关键词
胃肿瘤/AXIN/MACC1/免疫组织化学/预后Key words
Gastric neoplasm/AXIN/MACC1/Immunohistochemistry/Prognosis引用本文复制引用
朱博,王丹娜,龚晓萌,俞岚,武世伍,陶仪声..AXIN和MACC1蛋白在胃癌组织中的表达及其临床意义[J].四川大学学报（医学版）,2018,49(1):59-64,6.基金项目
安徽省高校自然科学研究重点项目(No.KJ2017A224)和蚌埠医学院自然科学基会重点项目(No.BYKY1711ZD)资助 （No.KJ2017A224）
