四川大学学报（医学版）2018，Vol.49Issue(1)：136-139,4.
157例感染性心内膜炎患者的病原菌构成及临床特点分析
Analysis of Pathogens and Clinical Characteristics in 157 Cases with Infective Endocarditis
摘要
Abstract
Objective To analyze the clinical characteristics of infective endocarditis (IE) in culture-positive patients,so as to provide the evidences for reasonable diagnosis and treatment of IE.Methods We performed a retrospective study of 157 culture-positive IE cases,which were diagnosed according to modified Duke criteria for IE from Jan.2008 to Aug.2015.Results The average age of 157 cases of IE was 40.85 years.One hundred and one patients (64.3％) had various underlying cardiac diseases,including congenital cardiovascular diseases in 44 cases and rheumatic heart diseases in 15 cases.The main clinical manifestations were anemia (147 cases,93.6 ％),fever (137 cases,87.3％) and heart murmur (120 cases,76.4％).Vegetation was found in 12 cases (7.6％) with transesophageal echocardiography (TEE) but not with transthoracic echocardiography (TTE).Culture results showed the most common causative microorganisms were Streptococci (76 cases,48.4％),with Viridans streptococci dominated in 70 cases,and Staphylococci (33 cases,21.0％) (Staphylococcus aureus dominated in 18 cases).All patients were treated with antimicrobial agents.Eighty-five patients (54.1％) received surgical intervention,of which 72 cases received valve replacement.Twenty-seven patients were cured,88 patients were markedly improved,38 patients discontinued treatment,and 4 patients died.The therapeutic efficacy of operation group was better.Conclusion The clinical characteristics of IE included:the age of onset increased,congenital heart disease was the most underlying disease,and Viridians streptococci was the most popular causative microorganism.Surgical therapy can effectively improve the outcomes of IE patients.关键词
感染性心内膜炎/致病菌/超声心动图/外科治疗Key words
Infective endocarditis/Causative microorganism/Echocardiography/Surgical treatment引用本文复制引用
赵菲菲,陆杨,叶慧,钟册俊,黄亮,吕晓菊..157例感染性心内膜炎患者的病原菌构成及临床特点分析[J].四川大学学报（医学版）,2018,49(1):136-139,4.基金项目
四川省科技厅计划项目(No.2014KJT026 2014SZ)资助 （No.2014KJT026 2014SZ）
