军事医学2017，Vol.41Issue(10)：810-813,863,5.DOI:10.7644/j.issn.1674-9960.2017.10.006
新型抗病毒药物GZ914处方前研究
Preformulation study on novel antiviral drug GZ914
侯冠华 1韩潇扬 2陈艳君 3靳倩 1王玉丽 1吴强2
作者信息
- 1. 河南大学药学院,河南开封 475001
- 2. 军事医学科学院毒物药物研究所,北京 100850
- 3. 战略支援部队航天系统部航天城门诊部,北京 100094
- 折叠
摘要
Abstract
Objective To study the physical-chemical parameters of antiviral drug GZ 914 and provide data for the preparation design .Methods The appearance , crystal structure and solubility of GZ 914 were investigated .An HPLC method was established to determine the content of GZ 914 in vitro before oil/water partition coefficient and solubility in different pH experiments were calculated .Results GZ914 was a straw yellow powder with a crystalline structure , low water-solubility and good lipotropy .The HPLC method had a good linear relationship within the range of 12-60 μg/ml (r=0.9998).The oil/water partition coefficient of GZ914 was 1.9.Conclusion This analytical method is accurate and reliable.The oil/water partition coefficient indicates that the drug could be formulated as an oral solid preparation.关键词
GZ914/处方前研究/油水分配系数/溶解度Key words
GZ914/preformulation/oil/water partition coefficient/solubility分类
医药卫生引用本文复制引用
侯冠华,韩潇扬,陈艳君,靳倩,王玉丽,吴强..新型抗病毒药物GZ914处方前研究[J].军事医学,2017,41(10):810-813,863,5.
