国际眼科杂志2018，Vol.18Issue(2)：376-378,3.DOI:10.3980/j.issn.1672-5123.2018.2.45
原发性翼状胬肉患者泪液中TNF-α和IFN-γ的表达
TNF-α and IFN-γin tear of patients with primary pterygium
摘要
Abstract
AIM: To study the roles of tumor necrosis factor alpha ( TNF-α) , interferon gamma ( IFN-γ) in pathogenesis of primary pterygium and to explore the mechanism of tears in pterygium.?METHODS: Concentrations of TNF-α and interferon gamma IFN - γ were quantified by enzyme - linked immunosorbent assay ( ELISA ) in asymptomatic control group (30 eyes of 30 healthy volunteers) and 60 primary pterygium patients ( 30 eyes of the 30 progressive cases, 30 eyes of the 30 quiescent cases) . The data was analyzed by analysis of variance.?RESULTS:The concentration of TNF-αand IFN-γin the patients with primary pterygium were statistically significant (P<0. 05), compared with the normal control group. Tear concentration of TNF-α was significantly higher in primary pterygium compared with the control group. Tear concentration of IFN - γ was significantly reduced in primary pterygium compared with the control group (P<0. 05).?CONCLUSION:TNF-α and IFN-γmay be important in the pathogenesis and development of pterygium tissues.It can provide some new directions and ideas for the treatment of primary pterygium.关键词
TNF-α/IFN-γ/原发性翼状胬肉Key words
tumor necrosis factor alpha/interferon gamma/primary pterygium引用本文复制引用
程燕,刘先宁,吴洁,肖湘华,潘士印,朱秀萍..原发性翼状胬肉患者泪液中TNF-α和IFN-γ的表达[J].国际眼科杂志,2018,18(2):376-378,3.基金项目
陕西省社会发展科技攻关项目(No. 2015SF206) （No. 2015SF206）
西安市卫生局课题项目(No. J2011004)Shaanxi Province Social Development and Technology Research Project ( No. 2015SF206 ) （No. J2011004）
Xi'an Health Bureau Project (No. J2011004) （No. J2011004）
