摘要
Abstract
Objective:To compare clinical outcomes among 17β-estradiol,HMG and tamoxifen preparation for thin endometrium in the frozen-thawed embryo transfer cycles in order to explore the effective endometrium preparation protocol for the patients with thin endometrium.Methods:The data of 427 patients with thin endometrium in the frozen-thawed embryo transfer cycles from January 2015 to October 2016 were retrospectively analyzed.The patients were given hormone replacement therapy (HRT group,n=123),human menopausal gonadotropin (HMG group,n=155),and tamoxifen (TAM group,n=149) to prepare the endometrium respectively.The endometrial thickness,clinical pregnancy rate,implantation rate,abortion rate,and ectopic pregnancy rate were compared among the three groups.Results:The endometrium in HMG group [(8.1 ± 1.6)mm]and TAM group [(8.2± 1.6)mm]were significantly thicker than that of HRT group[(6.8±0.4)mm].There were no significant differences in the clinical pregnancy rate,implantation rate,abortion rate,and ectopic pregnancy rate among the three groups (P＞0.05).However,the clinical pregnancy rate and the implantation rate were slightly higher and the abortion rate and ectopic pregnancy rate were slightly lower in the HMG group and the TAM group than those in the HRT group.The multiple follicles development rate of the HMG group was significantly higher than that of the TAM group (9.7％ vs.0％,P＜0.05).Conclusions:HMG and TAM,especially HMG,could slightly improve the embryo implantation rate,and reduce the ectopic pregnancy rate in patients with thin endometrium in FET cycles.The application of HMG in patients with high risk of OHSS should be prudent.关键词
冻融胚胎移植/薄型子宫内膜/17-β雌二醇/人绝经期促性腺激素/他莫昔芬Key words
Frozen-thawed embryo transfer/Thin endometrium/17β-Oestrogen/HMG/Tamoxifen
