生殖医学杂志2018，Vol.27Issue(2)：134-139,6.DOI:10.3969/j.issn.1004-3845.2018.02.007
IVF助孕中卵母细胞成熟率对ICSI临床结局的影响
Influence of oocyte maturation status on HCG day clinical outcomes in ICSI
摘要
Abstract
Objectives:To explore the clinical factors related with the oocyte maturity and the influence of oocyte maturation on embryo development and clinical outcomes in ICSI.Methods:The data of 427 ICSI cycles in the ART Department of the Forth Hospital of Shijiazhuang from March 2014 to April 2015 were retrospectively analyzed.The cycles were divided into four groups according tooocyte maturation rate:oocyte maturation rate ≥80％ in group A(n=283),60％-79％ in group B(n=124),＜ 60％ in group C(n=20).The age,duration of infertility,total doses & duration of gonadotropin(Gn) used,hormones levels on HCG day,E2 level/mature oocyte,number of mature oocytes,number of oocytes retrieved,number of M Ⅱ oocytes and oocytes retrieved rate;2PN fertilization rate,cleavage rate,transferable embryos rate,good quality embryo rate,blastocyst formation rate,cumulative pregnancy rate,and ovarian hyperstimulation syndrome(OHSS)rate were compared among the three groups.Results:There were no significant differences in age,duration of infertility(P＞0.05).The days and dosed of Gn used in group A [(12.46±2.27)days,(2 713.96±976.55)U] and group B[(12.23±1.78)days,(2 779.23 ± 1 098.21) U] were significantly less than those in group C [(13.65± 3.08) days,(3 365.00±1 125.93)U](P＜0.05).The E2 levels on HCG day in group A [(14 662.80±1 157.38)pmol/L]were significantly higher than those in group B [(13 556.60 ± 1 200.66)pmol/L] and group C [(10 560.56±1 338.43)pmol/L] (P＜0.05).The levels of LH & P,E2 level/mature oocyte and E2 level/oocyte were not significantly different among the three groups(P＞0.05).The number of mature oocytes,the number of oocytes retrieved and the number of M Ⅱ oocytes in group A were significantly more than those in group B and group C(P＜0.05).The retrieval oocyte rate(number of retrieval oocytes/ number of ≥14mm oocytes) in group A (99.28％) was significantly higher than that in group B (96.24％) and group C (95.21 ％)(P＜0.05).The normal fertilization rate and cleavage rate in group A (86.55 ％,99.17 ％)were significantly higher those in group B (78.19 ％,97.91 ％) and group C (79.82 ％,95.60 ％) (P ＜ 0.05).Thegood quality embryo rate and cumulative pregnancy rate in group A(48.03％,51.59％)and group B (44.58％,48.38％) were significantly higher than those in group C(39.62％,35.00％)(P＜0.05).The incidence of moderate-severe OHSS was not significantly different among the three groups(P＞ 0.05).Conclusions:Low oocyte maturation rate may be related to poor ovarian response or decreased sensitivity to Gn,and may affect fertilization and embryonic development potential,resulting in reduced numbers of embryos available for transplantation and reduced pregnancy rates.关键词
卵母细胞成熟/卵胞浆内单精子注射/胚胎发育Key words
Oocyte maturation/Intracytoplasmic sperm injection/Embryonic development引用本文复制引用
付蕾,朱玉林,袁景川,周莉,刘俊山,罗红,陶建芳,吴晓茜,孙梅..IVF助孕中卵母细胞成熟率对ICSI临床结局的影响[J].生殖医学杂志,2018,27(2):134-139,6.基金项目
河北省卫生厅医学科学研究重点课题资助项目(ZD20140024) （ZD20140024）
