生殖医学杂志2018，Vol.27Issue(2)：140-144,5.DOI:10.3969/j.issn.1004-3845.2018.02.008
GnRH激动剂长效剂型的两种促排卵方案在PCOS患者中的应用
Application of two long protocols with long-acting GnRH agonist for ovarian stimulation in PCOS patients
李苏萍 1刘海鹏 1陈艺 1杨帆 1贺平1
作者信息
- 1. 郴州市第一人民医院生殖医学中心,郴州423000
- 折叠
摘要
Abstract
Objective:To compare the clinic outcomes of two controlled ovarian stimulation (COS) protocols with long-acting GnRH agonist (GnRHa) in patients with polycystic ovary syndrome (PCOS).Methods:The data of PCOS patients undergone IVF/ICSI treatment including 423 cycles from January 2015 to June 2016 were retrospectively analyzed.The cycles were divided into two groups according to the regimen of long acting GnRHa used:the patients were used modified super-long GnRH agonist protocol in group A (n=223),and the patients were used low-dose long-acting GnRH agonist long protocol in group B (n=200).The general conditions,basic hormone levels,ovulation induction and pregnancy outcomes including implantation rate,clinical pregnancy rate,early abortion rate,birth rate and incidence of moderate and severe ovarion hyperstimulation syndrome (OHSS) were compared between the two groups.Results..There were no significant differences in the general conditions,basic hormone levels,total amount of Gn used,E2 & LH levels on HCG day and the number of oocytes retrieval between the two groups (P ＞ 0.05).The implantation rate (50.64％ vs.40.91％),clinical pregnancy rate (67.28％vs.55.48％),birth rate (60.49％ vs.45.89％) in group A were significantly higher than those in group B.The early abortion rate (5.50％ vs.9.88％) in group A was significantly lower than that group B (P＜0.05).The moderate and severe OHSS incidence in group A was slightly higher than that in group B (2.24％vs.2.0％),but the difference was not significant (P＞0.05).The 2PN fertilization rate(58.23％vs.57.31％),cleavage rate(95.85％ vs.95.01％) and high quality embryos rate(38.23％ vs.37.15％) in group A were higher than those in group B,but the differences were not significant(all P＞0.05).Conclusions:Compared with low-dose long-acting GnRH-a protocol,the modified super-long GnRH-a protocol can improve the clinical pregnancy outcome but not increase the incidence of moderate and severe OHSS,which can provide a choice for the treatment of PCOS.关键词
改良超长方案/多囊卵巢综合征/体外受精-胚胎移植/促排卵/结局Key words
Modified super-long GnRH agonist protocol/PCOS/IVF-ET/Super-ovulation/Pregnancy outcome引用本文复制引用
李苏萍,刘海鹏,陈艺,杨帆,贺平..GnRH激动剂长效剂型的两种促排卵方案在PCOS患者中的应用[J].生殖医学杂志,2018,27(2):140-144,5.
