王心龙 1向斌 1李亚美 1耿福能 2晏永明 3程永现1
作者信息
- 1. 中国科学院昆明植物研究所植物化学与西部植物资源持续利用国家重点实验室,昆明650201
- 2. 药用美洲大蠊四川省重点实验室,成都610000
- 3. 深圳大学医学部药学院,深圳518060
- 折叠
摘要
Abstract
Twenty-twocompoundswere isolatedfrom Periplaneta americana.Their structures were identified as glycerol (1),salicylic acid (2),phenylalanine (3),tryptophan (4),uracil (5),adenine (6),cyclo (Pro-Thr) (7),cyclo (ProAla) (8),cyclo (Ala-Val) (9),cyclo (Gly-Ile) (10),cyclo (Gly-Leu) (11),inosine (12),adenosine (13),cyclo (Leu-Ser) (14),cyclo(Phe-Ser) (15),(3S,6S)-3-phenylmethyl-6-amidocarboxymethyl-piperazine-2,5-dione,cis-cyclo (Asn-Phe) (16),cyclo (Tyr-Gly) (17),cyclo (Tyr-Ala) (18),cyclo (Tyr-Ser) (19),cyclo (Tyr-Thr) (20),cyclo (Tyr-Asp) (21) andcordyrrole A (22),respectively,by spectroscopic methods.Compounds 20 and 21 are new naturally occurring substances.In addition,compounds 7-11 and 14-22 were isolated from the title insect species for the first time.In addition,biological evaluation towards nitric oxide (NO) production and angiogenesis activity was conducted.关键词
美洲大蠊/环二肽/一氧化氮生成/血管生成活性Key words
Periplaneta americana/cyclic dipeptides/NO production/angiogenesis activity分类
医药卫生
