新医学2018，Vol.49Issue(1)：15-18,4.DOI:10.3969/j.issn.0253-9802.2018.01.004
氧化应激与肺纤维化肺泡上皮凋亡的研究进展
Research progress on oxidative stress and alveolar epithelial cell apoptosis during pulmonary fibrosis
王聪 1董春玲1
作者信息
- 1. 130041长春,吉林大学第二医院呼吸和危重症医学科
- 折叠
摘要
Abstract
Oxidative stress is a stress injury of oxidant/antioxidant imbalance,which is caused by excess intracellular reactive oxygen species.Pulmonary fibrosis is a chronic,progressive and fibrous interstitial disease,which is characterized by epithelial damage and myofibroblast activation induced by excessive extracellular matrix collagen deposition in the distal pulmonary interstitium.The exact pathogenesis of pulmonary fibrosis remains elusive.In recent years,multiple studies have demonstrated that oxidative stress plays a pivotal role in the formation of pulmonary fibrosis.Oxidative stress can also induce the apoptosis of alveolar epithelial cells,which is probably a vital factor for the early incidence and progression of pulmonary interstitial fibrosis.This article summarized the research progress on the oxidative stress and alveolar epithelial cell apoptosis during pulmonary fibrosis.关键词
氧化应激/特发性肺纤维化/肺泡上皮细胞凋亡Key words
Oxidative stress/Idiopathic pulmonary fibrosis/Alveolar epithelial cell apoptosis引用本文复制引用
王聪,董春玲..氧化应激与肺纤维化肺泡上皮凋亡的研究进展[J].新医学,2018,49(1):15-18,4.
