针刺研究2018，Vol.43Issue(1)：43-47,5.DOI:10.13702/j.1000-0607.160781
经皮穴位电刺激对孕晚期抑郁及血清炎性细胞因子的影响
Effects of Transcutaneous Electrical Acupoint Stimulation for Depression in Late Pregnancy and Impacts on Inflammatory Cytokines
摘要
Abstract
Objective To assess the safety and efficacy of transcutaneous electrical acupoint stimulation (TEAS) for depression in late pregnancy and impacts on inflammatory cytokines.Methods A total of 150 pregnant women with depression in late pregnancy were randomized into a high intensity group (n =52),a low intensity group (n =49) and a control group (n =49).TEAS was applied at bilateral Neiguan (PC 6) and Shenmen (HT 7) for 6 weeks.The intensities of TEAS in the high intensity group,the low intensity group and the control group were 10,5 and 0 mA,respectively.During the process of TEAS,the blood pressure,pulse,uterine contraction and the fetal heart rate were recorded.Depression was evaluated by 24-item Hamilton depression scale (HAMD) before TEAS and after 2-week,4-week,6-week treatment.Serum levels of tumor necrosis factor-α (TNF-α),interleukin-1 β (IL-1 β) and IL-6 were detected by enzyme-linked immunosorbent assay (ELISA) before and after 6-week treatment.Delivery outcomes were observed.The correlation was analyzed between HAMD difference value and the difference values of TNF-α,IL-1 β and IL-6,respectively.Results The blood pressure,pulse and fetal heart rate had no statistical significance before and after treatment in the three groups (P＞0.05).The HAMD scores at all the time points were lower than that before treatment in the high intensity group (P＜0.05),which were lower compared with those in the low intensity group and the control group (P＜0.05).The HAMD score in the low intensity group decreased after 6-week treatment compared with that before treatment and was lower than that in the control group (P＜0.05).The serum levels of IL-1 β and IL-6 in the high intensity group decreased compared with those before treatment and were lower compared with those in the low intensity group and the control group after 6-week treatment (P＜0.05).There was no significant difference in the deliver outcomes among the three groups (P＞0.05).The variation of HAMD score did not have significant correlation with those of TNF-α,IL-1 β and IL-6 (P＞0.05).Conclusion TEAS is safe and effective for depression in late pregnancy and can regulate the serum levels of IL-1 β and IL-6 without influencing on delivery outcome.关键词
经皮穴位电刺激/抑郁/孕晚期/炎性细胞因子Key words
Transcutaneous electrical acupoint stimulation (TEAS)/Depression/Late pregnancy/Inflammatory cytokines分类
医药卫生引用本文复制引用
陈伟业,利莉,汪慧媛,江楠..经皮穴位电刺激对孕晚期抑郁及血清炎性细胞因子的影响[J].针刺研究,2018,43(1):43-47,5.基金项目
广州市天河区科技计划项目(No.201504 KW 006) （No.201504 KW 006）
