中风与神经疾病杂志2018，Vol.35Issue(1)：14-17,4.
变应性肉芽肿性血管炎14例临床表现及周围神经损害
Clinical Manifestations and Peripheral Neuropathy in 14 Patients with Allergic Granulomatous Vasculitis
摘要
Abstract
Objective Analyze the clinical characteristics of eosinophilic granulomatosis with polyangiitis ( Churg-Strauss syndrome,CSS) and peripheral neuropathy,and to improve the diagnosis and treatment of CSS. Methods Medical records from all patients diagnosed with CSS who had been treated at Peking University Third Hospital,China,between Jan-uary 2005 and December 2016 were retrospectively reviewed to identify the clinical manifestations and the damage of pe-ripheral nerve. Results 14 patients were diagnosed with CSS. 10 (71. 4％) of them were males,and from 20 to 78 (53. 6 ± 16. 2) years old. Peripheral blood eosinophils increased,and the mean of eosinophils was 20. 7％,(10. 3％ ～55％). The most frequently involved organ respiratory system (100％),9 cases of asthma (64. 3％) and 12 cases of pulmonary in-vasion (85. 7％). Peripheral nerve injuries occurred in 6 patients (42. 9％),especially in the lower extremities,and both the motor and sensory nerves were involved. The misdiagnosis rate of CSS at the early onset was very high (64. 3％),and mean time of the onset to diagnosis interval was 15. 9 months (1～72 months). Conclusion CSS was a vasculitis involved multisystem,and with a high rate of misdiagnosis. The patients with elevated eosinophils and axonal impairment of peripher-al neuropathy,should be paid attention to the possibility of CSS.关键词
变应性肉芽肿性血管炎/周围神经/嗜酸性粒细胞Key words
Allergic granulomatous vasculitis/Churg-Strauss syndrome/Peripheral nerves/Eosinophils分类
医药卫生引用本文复制引用
赵海燕,刘向一,孙阿萍,张朔,樊东升..变应性肉芽肿性血管炎14例临床表现及周围神经损害[J].中风与神经疾病杂志,2018,35(1):14-17,4.基金项目
国家自然科学基金(No.81471184) （No.81471184）
