中国美容医学2018，Vol.27Issue(1)：74-76,3.
不同来源黑色素瘤BRAF V600E基因突变分析
Analysis of BRAF Gene Mutation of Melanoma Derived from Different Sources
摘要
Abstract
Objective To investigate the relationship between BRAF V600E gene mutation and melanoma derived from non pigmented nevus or pigmented nevus. Methods The melanoma tissue specimens in 62 Patients from non pigmented nevus and 22 patients from melanocytic nevus were collected,PCR and DNA sequencing were used to detect the mutation of V600E locus in BRAF gene. Results The BRAF gene mutation rates respectively was 45.2％ in the melanoma derived from non pigmented nevus,11.1％ in the melanoma derived from congenital small nevi and 15.4％ in the melanoma derived from acquired melanocytic nevus, there was a significant difference(χ2=6.972,P<0.05). There is no significant difference in the gene mutation rate of the different sex and locations (acromelic, non acromegaly, mucous membrane) in melanoma derived from different sources(P>0.05). Conclusion BRAF V600E gene mutation appear to be closely related with the origins of melanoma derived from non pigmented nevus or congenital nevus or acquired nevus, but uncorrelated with gender and lesion sites.关键词
黑色素瘤/BRAFV600E基因/痣/色素Key words
melanoma/BRAF V600E gene/nevus/pigment分类
医药卫生引用本文复制引用
高正君,谢沛霖,司小强,杨国虎,薛晓东,徐靖宏..不同来源黑色素瘤BRAF V600E基因突变分析[J].中国美容医学,2018,27(1):74-76,3.基金项目
甘肃省卫生行业科研项目(GSWSKY2017-54) （GSWSKY2017-54）
