中国全科医学2018，Vol.21Issue(3)：330-333,337,5.DOI:10.3969/j.issn.1007-9572.2017.00.249
舒肝解郁胶囊治疗慢性乙型肝炎伴轻中度抑郁的临床效果及其对外周血淋巴细胞亚群的影响研究
Effect of Shuganjieyu Capsule on Peripheral Blood Lymphocyte Subsets in Patients with Chronic Hepatitis B Combined with Mild to Moderate Depression
摘要
Abstract
Objective To explore the effect of Shuganjieyu capsule on the peripheral blood lymphocyte subsets in patients with chronic hepatitis B (CHB) combined with mild-moderate depression, hoping to provide a reference for clinical treatment.Methods We enrolled 70 outpatients and inpatients with CHB from Hebei General Hospital from January 2015 to January 2016 and assigned 40 cases of them to the CHB with mild-moderate depression group (Hamilton depression scores ranged 8-35 ) and other 30 cases to the CHB group (CHB without depression) based on the assessment results of 24-item Hamilton Depression Rating Scale (HAMD-24). We compared CD3+, CD4+ and CD8+ T lymphocyte percentages as well as the CD4+/CD8+value, CD19+ B-lymphocyte percentage and HAMD scores between these two groups and analyzed the correlations between the cell percentage of the peripheral blood lymphocyte subsets and the HAMD score for CHB with mild-moderate depression group. The CHB with mild-moderate depression group were further randomly divided into the experimental subgroup (20 cases treated with Shuganjieyu capsule plus conventional liver-protecting drugs), and the control subgroup (20 cases treated with conventional liver-protecting drugs). Treatment for both subgroups lasted for 4 weeks. Comparisons were made between the two subgroups in the HAMD scores and the peripheral blood lymphocyte subsets before and after treatment.Results The CD3+ , CD4+ and CD8+ T lymphocyte percentages as well as the CD19+ B-lymphocyte percentage in CHB with mild-moderate depression group were lower than the CHB group (P<0.05). There was a negative correlation between CD8+ T lymphocyte percentage and HAMD score in CHB with mild-moderate depression group (r=-0.353,P<0.05) and a positive correlation between CD4+/CD8+ and HAMD score (r=0.371, P<0.05), but there was no linear correlation between HAMD score and CD3+, CD4+ T lymphocyte percentages or CD19+ B-lymphocyte percentage (r=-0.121, -0.127, 0.069, respectively, allP>0.05). Before treatment, there were no significant differences between the experimental subgroup and control subgroup in CD3+, CD4+ and CD8+ T lymphocyte percentages as well as CD4+/CD8+ , CD19+B-lymphocyte percentage and HAMD score (P>0.05). After treatment, CD3+, CD4+ and CD8+ T lymphocyte percentages of the experimental subgroup were higher, while HAMD scores were lower compared with the control subgroup (P<0.05). Compared with before treatment, the experimental subgroup had higher CD3+, CD4+ and CD8+ T lymphocyte percentages and lower HAMD scores after treatment (P<0.05).Conclusion In CHB patients with mild-moderate depression, cell and humoral immune disorders can be found, and the HAMD score correlates with the lymphocyte subsets. It is inferred that depression may deteriorate the conditions and prognosis of CHB, and Shuganjieyu capsule can improve the depression as well as the immune function of the patients.关键词
乙型肝炎,慢性/抑郁/淋巴细胞亚群/舒肝解郁胶囊Key words
Hepatitis B/chronic/Depression/Lymphocyte subsets/Shuganjieyu capsule分类
医药卫生引用本文复制引用
苏少慧,刘洪娜,胡义亭,张建,侯洪涛,王玉珍..舒肝解郁胶囊治疗慢性乙型肝炎伴轻中度抑郁的临床效果及其对外周血淋巴细胞亚群的影响研究[J].中国全科医学,2018,21(3):330-333,337,5.基金项目
河北省中医药管理局资助项目(2016059) （2016059）
