中国兽医科学2018，Vol.48Issue(1)：101-106,6.DOI:10.16656/j.issn.1673-4696.2018.0016
氟苯尼考微囊的体外释放特性考察
Study on in-vitro release behavior of florfenicol microcapsules
摘要
Abstract
The in vitro release behavior of florfenicol microcapsules was investigated in phosphate buffer solution(pH6.8) containing 5mL/LTween 80and compared with florfenicol bulk drug.The release model of florfenicol microcapsules was also fitted.The results showed that florfenicol bulk drug was almost totally released at 15 min,but the drug release of the two self-prepared florfenicol microcapsules could sustain to 4 h.The cumulative release rate of sample 2 was also found to be slower than that of sample 1.And the release profile of self-prepared microcapsules of sample land 2 conformed to RitgerPeppas equation and First-order equation,respectively.In conclusion,the two self-prepared florfenicol microcapsules exhibited sustained release effects with different release mechanisms,providing a reference to future clinical studies and use of the self-prepared florfenicol microcapsules.关键词
氟苯尼考/微囊/缓释/体外释放Key words
florfenicol/microcapsule/sustained-release/in-vitro release分类
农业科技引用本文复制引用
梁劲康,张桂君,吴志玲,梁惠莲,廖陶雪,方炳虎..氟苯尼考微囊的体外释放特性考察[J].中国兽医科学,2018,48(1):101-106,6.基金项目
国家重点研发计划项目(2017YFD0501400) （2017YFD0501400）
广东省战略性新兴产业核心技术攻关项目(2012A020800004) （2012A020800004）
